{"id":"W3139289284","doi":"10.1055/a-1458-2980","title":"CuI-Catalyzed Ullmann-Type Coupling of Phenols and Thiophenols with 5-Substituted 1,2,3-Triiodobenzenes: Facile Synthesis of Mammary Carcinoma Inhibitor BTO-956 in One Step","year":2021,"lang":"en","type":"article","venue":"Synthesis","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"Deanship of Academic Research, University of Jordan","keywords":"Regioselectivity; Chemistry; Nucleophile; Steric effects; Thioether; Phenols; Ether; Substituent; Combinatorial chemistry; Catalysis; Organic chemistry; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005175963,0.0003472871,0.0009123127,0.0002404267,0.00007864458,0.00004085261,0.0002935243,0.0002588427,0.001015014],"category_scores_gemma":[0.002381835,0.0003582499,0.0001199305,0.0008850232,0.0002044698,0.0002346631,0.0001884845,0.0001916797,0.000008762106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349889,"about_ca_system_score_gemma":0.0004531944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002361115,"about_ca_topic_score_gemma":0.00009530238,"domain_scores_codex":[0.9974491,0.0000654755,0.0008653288,0.0006718975,0.000605672,0.0003425087],"domain_scores_gemma":[0.9958893,0.002177317,0.0004262539,0.0008958239,0.0004794108,0.0001319047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005680092,0.0005457457,0.02749803,0.002326467,0.0004396077,0.00007941578,0.0005459783,0.0007957526,0.9593688,0.0009946367,0.00006404793,0.006773503],"study_design_scores_gemma":[0.0007307789,0.00001459377,0.004186215,0.000926705,0.0002750414,0.00004049092,0.001083826,0.001649388,0.99036,0.0001017095,0.0002423251,0.0003889214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928001,0.001337685,0.003107193,0.000131745,0.00009451719,0.0001898014,0.0002216814,0.00007178413,0.002045484],"genre_scores_gemma":[0.9824829,0.0001804695,0.01676915,0.00001192127,0.00008345368,0.0000780272,0.0000722773,0.00006421929,0.0002576311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03099119,"threshold_uncertainty_score":0.9998982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745716986629507,"score_gpt":0.2417596196677876,"score_spread":0.2143024498014925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}