{"id":"W3139290764","doi":"10.1158/1078-0432.ccr-20-4068","title":"Structural Variants at the <i>BRCA1/2</i> Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Imperial Biomedical Research Centre; Medical Research Council; Sierra Oncology; National Institute for Health and Care Research; Cancer Research UK; NuCana; Ovarian Cancer Action; AstraZeneca; UK Research and Innovation; Wellcome Trust; Pancreatic Cancer UK; Beatson Cancer Charity; Pfizer","keywords":"Serous fluid; Biology; Ovarian carcinoma; Serous carcinoma; Structural variation; Homologous recombination; Somatic cell; Ovarian cancer; Homologous chromosome; Genome; Genetics; Carcinoma; Cancer; Cancer research; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002825357,0.0001614937,0.0002024205,0.000550253,0.000194511,0.000368548,0.0001711647,0.0001924947,0.001104567],"category_scores_gemma":[0.0007218024,0.0001216864,0.0001890493,0.0005105291,0.0002806714,0.000113378,0.0002601348,0.0002315711,0.0001237524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267336,"about_ca_system_score_gemma":0.0001323309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006994038,"about_ca_topic_score_gemma":0.001125119,"domain_scores_codex":[0.9998236,0.00002647874,0.0000236032,0.00006054441,0.00004571435,0.00002005885],"domain_scores_gemma":[0.9993342,0.0001251888,0.0003610438,0.00007627543,0.00003058777,0.00007263669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005921113,0.00003114285,0.925693,0.00006742083,0.0001312996,0.0005949834,0.00008736828,0.0002615294,0.0661136,0.00008520403,0.0001634532,0.006178912],"study_design_scores_gemma":[0.00001011756,0.0001045903,0.9904577,0.000006389969,0.00005464778,0.002210962,0.00006840093,0.0003098143,0.006428544,0.000074824,0.0002703287,0.0000036504],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992602,0.0002287298,0.0001899183,0.00001068338,0.000001440289,0.000003272457,0.0001720981,0.00001000701,0.0001236806],"genre_scores_gemma":[0.9996057,0.00005818038,0.0001191107,0.000009488724,0.000002643895,0.000001663643,0.0001687743,0.000002724591,0.000031691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001104567,"threshold_uncertainty_score":0.00369513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1750997976526971,"score_gpt":0.4681848292935828,"score_spread":0.2930850316408858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}