{"id":"W3139291984","doi":"10.1101/2021.03.19.436221","title":"Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Neuroblastoma; Blockade; Osteosarcoma; Cancer research; Antibody; CD47; Medicine; Immunology; Internal medicine; Biology; Cell culture; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000243053,0.0004137543,0.000385223,0.0002503457,0.0001066664,0.0002153258,0.000277572,0.0003198464,0.001046752],"category_scores_gemma":[0.00009236263,0.0001068849,0.0003208453,0.0001405798,0.0001874441,0.0001722723,0.0002020031,0.0005961987,0.0002801415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002734822,"about_ca_system_score_gemma":0.0003935259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005765507,"about_ca_topic_score_gemma":0.001840233,"domain_scores_codex":[0.9998023,0.00004465587,0.0000134809,0.0000190002,0.00003221157,0.00008842833],"domain_scores_gemma":[0.9999385,0.00001115952,0.00001046135,0.000008068727,0.000005351148,0.00002639824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001559297,0.001675867,0.0006938541,0.0001478852,0.0000630025,0.0001285063,0.0000305959,0.0006920163,0.980451,0.0003056547,0.000537553,0.01371464],"study_design_scores_gemma":[0.0006169797,0.01257345,0.006491356,0.00001288428,0.0000848202,0.0004610734,0.00003219854,0.002785053,0.971033,0.00007884283,0.005820607,0.000009822912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950054,0.00124531,0.001117412,0.000137595,0.00005134216,0.00007129478,0.0001328785,0.0000785551,0.002160192],"genre_scores_gemma":[0.9962197,0.00078454,0.001214084,0.00009558446,0.00002700195,0.00007019427,0.0002589661,0.00001052634,0.001319371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046752,"threshold_uncertainty_score":0.003501713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165598373980513,"score_gpt":0.2723483099955803,"score_spread":0.2606923262557752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}