{"id":"W3139323237","doi":"10.21203/rs.3.rs-258240/v1","title":"dentification of novel insulin resistance related ceRNA network: LncRNA, RP11‐773H22.4; miR-3163, miR-1; mRNAs:RET , IGF1-R, m-TOR, GLUT-4, AKT2 in T2DM and its potential editing by CRISPR/Cas9","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Competing endogenous RNA; Biology; microRNA; Downregulation and upregulation; CRISPR; Gene; Computational biology; Cas9; Gene expression; Genetics; Cancer research; Long non-coding RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001965633,0.0003816663,0.0002874854,0.0003284467,0.0001960381,0.0004723082,0.0001943382,0.0002628666,0.001453654],"category_scores_gemma":[0.0002580258,0.0001720481,0.00033827,0.0001888399,0.0002381393,0.0001737784,0.0002751637,0.0003466799,0.0003951174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003067574,"about_ca_system_score_gemma":0.0002678138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000357163,"about_ca_topic_score_gemma":0.0005296801,"domain_scores_codex":[0.9997548,0.0000230173,0.00002031549,0.0001165682,0.00005726016,0.00002808938],"domain_scores_gemma":[0.9997891,0.00003810865,0.00008345959,0.00002982808,0.00002798699,0.00003157818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002170049,0.00002185727,0.002759255,0.00008526398,0.00002413926,0.000349378,0.00002442432,0.0003589936,0.9917839,0.0002099444,0.0001009587,0.004065004],"study_design_scores_gemma":[0.00002252267,0.0002429716,0.0173368,0.00001666415,0.0001085539,0.002037459,0.00005183281,0.005477699,0.9689078,0.000169793,0.005613538,0.00001438442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751089,0.00107695,0.01979774,0.0001170865,0.00006373743,0.000053869,0.001123247,0.0003855883,0.002272938],"genre_scores_gemma":[0.9851161,0.0002728131,0.01091064,0.00006812072,0.00001293957,0.0000583358,0.001451595,0.00006538248,0.002044107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453654,"threshold_uncertainty_score":0.004863024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02760458679486854,"score_gpt":0.3431430903986448,"score_spread":0.3155385036037763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}