{"id":"W3139357521","doi":"10.3390/ijms22062939","title":"Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Ministry of Science Research and Technology; Centro de Investigación Biomédica en Red de Salud Mental","keywords":"Substantia nigra; Locus coeruleus; Dopamine; Monoamine neurotransmitter; Pars compacta; Transgene; Dopaminergic; Mutant; Alpha-synuclein; Midbrain; Genetically modified mouse; Chemistry; Systemic administration; Pharmacology; Biology; Cell biology; Parkinson's disease; Internal medicine; Endocrinology; Central nervous system; In vivo; Biochemistry; Serotonin; Medicine; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001482446,0.0007340917,0.0003953725,0.0006013107,0.0001814411,0.0003135256,0.0002898808,0.000616916,0.001040166],"category_scores_gemma":[0.00008273658,0.0002899482,0.0003676064,0.0002232507,0.0003841104,0.0002872887,0.0001399376,0.0009162831,0.0003470583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000332707,"about_ca_system_score_gemma":0.0002747484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008965022,"about_ca_topic_score_gemma":0.001762156,"domain_scores_codex":[0.9998301,0.00001581665,0.00002289973,0.00005611694,0.00003947251,0.00003558885],"domain_scores_gemma":[0.9998199,0.00001881194,0.00006476793,0.00001452701,0.00001738348,0.00006459528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008471332,0.00005168598,0.00005025377,0.00001695157,0.000005998386,0.0000404542,0.00001018268,0.00001759111,0.9993167,0.00003779729,0.00001581736,0.0003519],"study_design_scores_gemma":[0.00004352508,0.001075077,0.001627397,0.000006053844,0.00003679928,0.0002683803,0.00001850555,0.0006256775,0.9953979,0.00004240518,0.0008530558,0.000005264709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943479,0.0009008289,0.002678279,0.000140334,0.00005582633,0.00007503826,0.0004172862,0.0002333943,0.0011511],"genre_scores_gemma":[0.9869648,0.001315774,0.005054534,0.00009249825,0.00003155404,0.0001315593,0.0008361008,0.00005496341,0.005518132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040166,"threshold_uncertainty_score":0.00347966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04078377529045148,"score_gpt":0.3469315405354511,"score_spread":0.3061477652449996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}