{"id":"W3139367385","doi":"10.4049/jimmunol.2001340","title":"CD154 Resistant to Cleavage from Intracellular Milieu and Cell Surface Induces More Potent CD40-Mediated Responses","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Heart and Stroke Foundation of Canada","keywords":"CD154; Cleavage (geology); Intracellular; Cell biology; Mutant; CD40; Cell membrane; Chemistry; Extracellular; Cell; Biology; Molecular biology; Biochemistry; In vitro; Cytotoxic T cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002901733,0.000675943,0.0005569925,0.000329407,0.0001070497,0.0004235346,0.0001553182,0.0004900488,0.001909645],"category_scores_gemma":[0.0002491715,0.0001391996,0.0003886423,0.0001748353,0.0001855851,0.00019106,0.0002521663,0.001386053,0.000529644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301483,"about_ca_system_score_gemma":0.0001267679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001449604,"about_ca_topic_score_gemma":0.0001680489,"domain_scores_codex":[0.9994221,0.0001322419,0.00007805322,0.00008675264,0.0001392281,0.000141601],"domain_scores_gemma":[0.9996686,0.00008489223,0.00006602006,0.00006882589,0.00003529165,0.00007642185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007336695,0.00007014596,0.00004011506,0.000025123,0.000003483301,0.0000427997,0.000008591132,0.00002229105,0.9993114,0.00002685642,0.00001815152,0.0003576661],"study_design_scores_gemma":[0.00002635526,0.0009295609,0.001154423,0.000005155748,0.00001853689,0.0003859611,0.00001801217,0.0002714876,0.995647,0.00003218878,0.001508603,0.00000271813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962076,0.001011523,0.001280217,0.00005975532,0.00006089496,0.00003787528,0.0001715512,0.00005602272,0.001114523],"genre_scores_gemma":[0.9947172,0.0004069073,0.001590136,0.00008731032,0.00003995982,0.00004661318,0.0005616861,0.00001962102,0.002530624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001909645,"threshold_uncertainty_score":0.006388366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106756986138601,"score_gpt":0.2267548353268804,"score_spread":0.2160791367130203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}