{"id":"W3139423335","doi":"10.1038/s41591-021-01299-5","title":"Placebo use and unblinding in COVID-19 vaccine trials: recommendations of a WHO Expert Working Group","year":2021,"lang":"en","type":"letter","venue":"Nature Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Public Health Ontario; University of Toronto","funders":"","keywords":"Vaccination; Medicine; Coronavirus disease 2019 (COVID-19); Clinical trial; Placebo; Immunotherapy; Immunology; Pandemic; Immune system; Virology; Alternative medicine; Internal medicine; Disease; Infectious disease (medical specialty); Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2792099,0.002814775,0.009496826,0.004763161,0.006716563,0.01348071,0.009767564,0.1288616,0.006098033],"category_scores_gemma":[0.4669234,0.003698789,0.01022339,0.00424569,0.01313536,0.01163867,0.004813424,0.07821808,0.009576303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007897048,"about_ca_system_score_gemma":0.03222734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007397431,"about_ca_topic_score_gemma":0.01654156,"domain_scores_codex":[0.7000266,0.1831141,0.06716897,0.009676579,0.03322072,0.006793015],"domain_scores_gemma":[0.3777376,0.487151,0.03406096,0.01721598,0.06716311,0.01667127],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001853632,0.0001999882,0.001579574,0.002879204,0.0007283972,0.0007888371,0.001137629,0.000257344,0.000927381,0.007770552,0.910333,0.07154439],"study_design_scores_gemma":[0.007663227,0.0006735771,0.006585014,0.02670421,0.002141745,0.001095942,0.0008983427,0.002504332,0.002107702,0.0398117,0.9092539,0.0005603099],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0005115737,0.01017834,0.005421715,0.9449096,0.03042239,0.000987282,0.0005440361,0.0002658177,0.006759178],"genre_scores_gemma":[0.004348328,0.002841549,0.01844403,0.944886,0.02356194,0.002249863,0.0001845737,0.0002181742,0.003265572],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.7207901,"threshold_uncertainty_score":0.8888626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1659510605602163,"score_gpt":0.4441312083223003,"score_spread":0.278180147762084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}