{"id":"W3139510287","doi":"10.1038/s41416-021-01297-x","title":"Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer","year":2021,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; Dan L. Duncan Cancer Center, Baylor College of Medicine; Cancer Prevention and Research Institute of Texas; U.S. Department of Health and Human Services","keywords":"Lactate dehydrogenase A; Glycolysis; Head and neck squamous-cell carcinoma; Cancer research; Warburg effect; Clonogenic assay; Lactate dehydrogenase; Small hairpin RNA; Cancer cell; Biology; Cancer; Head and neck cancer; Cell; Internal medicine; Medicine; Biochemistry; Metabolism; Enzyme; Gene knockdown; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007803065,0.0005486552,0.0007203769,0.000611121,0.0003643896,0.001363111,0.001023118,0.0006525347,0.003364489],"category_scores_gemma":[0.0007663954,0.0002967499,0.0006045615,0.0003484248,0.0005099003,0.0007460297,0.000609634,0.002307313,0.0006329643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008253256,"about_ca_system_score_gemma":0.001707038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001116499,"about_ca_topic_score_gemma":0.002840139,"domain_scores_codex":[0.9997424,0.00006938034,0.00001793328,0.00005543476,0.00005217651,0.00006269343],"domain_scores_gemma":[0.9998484,0.00004494852,0.00003015655,0.00001825463,0.00002945135,0.00002882332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00166642,0.0020089,0.003409632,0.0007111348,0.0002580312,0.0006302084,0.0001743549,0.01943672,0.6324087,0.0312852,0.005274348,0.3027363],"study_design_scores_gemma":[0.002504172,0.01750747,0.009793873,0.00059369,0.0009894785,0.003890841,0.000683698,0.05490885,0.6297507,0.03426599,0.2448463,0.0002649158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4974509,0.06564646,0.3680269,0.0205319,0.001743372,0.004053332,0.001778151,0.001697447,0.03907138],"genre_scores_gemma":[0.8755151,0.02095053,0.09526879,0.002235498,0.0002147575,0.0008662847,0.0008703609,0.0001172626,0.0039613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003364489,"threshold_uncertainty_score":0.01125538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822501151553502,"score_gpt":0.3313329280937148,"score_spread":0.3031079165781798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}