{"id":"W3139637058","doi":"10.1007/s10072-021-05203-4","title":"Disability progression in multiple sclerosis is associated with plasma neuroactive steroid profile","year":2021,"lang":"en","type":"article","venue":"Neurological Sciences","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Alberta","funders":"Canada Excellence Research Chairs, Government of Canada; Alberta Innovates - Health Solutions","keywords":"Multiple sclerosis; Neuroactive steroid; Expanded Disability Status Scale; Allopregnanolone; Internal medicine; Endocrinology; Pregnanolone; Medicine; Glutamine; Neurology; Amino acid; Chemistry; Immunology; Psychiatry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009022902,0.0002699562,0.0004282678,0.001420785,0.0005710731,0.001040417,0.0002470105,0.0004748819,0.002008662],"category_scores_gemma":[0.00384011,0.0001600063,0.0004924839,0.001580231,0.0003685134,0.0005590847,0.0007019062,0.0006544452,0.0003398671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002642129,"about_ca_system_score_gemma":0.0004277293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004089802,"about_ca_topic_score_gemma":0.004186836,"domain_scores_codex":[0.9993784,0.0002072038,0.00009974901,0.00007857671,0.0001270774,0.0001088797],"domain_scores_gemma":[0.996559,0.0007822285,0.001539153,0.0001775157,0.0003506181,0.0005915425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00083653,0.0001216743,0.9924529,0.00003593425,0.0001705495,0.0002022031,0.0001938623,0.00003142672,0.0006483623,0.00003011607,0.00007780659,0.00519862],"study_design_scores_gemma":[0.000006814575,0.0001921423,0.9990996,0.000008815772,0.0000504255,0.0001830443,0.0001686352,0.00002967146,0.00007420861,0.00003397978,0.0001498892,0.000002734097],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997453,0.001146804,0.00005925017,0.00005270754,0.00001021578,0.000005566598,0.0001839809,0.000006320259,0.001082065],"genre_scores_gemma":[0.9992179,0.0002199547,0.00004087756,0.00001709346,0.00001238348,0.000003672355,0.0001616856,0.000001318441,0.0003250846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004089802,"threshold_uncertainty_score":0.008131981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1480046342675449,"score_gpt":0.3422321300419837,"score_spread":0.1942274957744388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}