{"id":"W3139648099","doi":"10.1101/2021.04.07.438788","title":"Suppression of aminoglycoside-induced premature termination codon readthrough by the TRP channel inhibitor AC1903","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; E-Rare; British Heart Foundation; Wellcome Trust","keywords":"TRPC5; TRPC; Transient receptor potential channel; TRPC1; Repressor lexA; Chemistry; Aminoglycoside; Cell biology; Biophysics; Biochemistry; Biology; Gene; Gene expression; Receptor; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669037,0.0003599713,0.0003483875,0.000216393,0.0001346224,0.0002531658,0.0002690291,0.0002216496,0.0009676786],"category_scores_gemma":[0.0001674835,0.00009280866,0.000316849,0.0001653268,0.0001779799,0.0001068949,0.0001403169,0.0006154302,0.0002456607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001929028,"about_ca_system_score_gemma":0.0001802968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008168447,"about_ca_topic_score_gemma":0.0008964792,"domain_scores_codex":[0.9998198,0.00003848301,0.00002453549,0.00002458672,0.00004289689,0.0000496225],"domain_scores_gemma":[0.9998535,0.00004481149,0.00003350533,0.00001714006,0.00001904784,0.0000319657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001593992,0.00006565973,0.0001071556,0.00002500609,0.000006248262,0.00003195873,0.000007616077,0.00004422536,0.9982513,0.00003523137,0.00003843487,0.001227785],"study_design_scores_gemma":[0.00003834868,0.0009820516,0.001733793,0.000003476282,0.00001649487,0.0001608078,0.00001144242,0.001067175,0.9951788,0.00001220137,0.0007928571,0.000002653058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995924,0.001243478,0.001510198,0.00006292646,0.00003258296,0.00004331105,0.0002342025,0.0001045283,0.0008448863],"genre_scores_gemma":[0.9976688,0.0005054786,0.00104172,0.0000296228,0.00001235927,0.00002494178,0.0002877768,0.0000200766,0.0004091176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009676786,"threshold_uncertainty_score":0.003237188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372235087823469,"score_gpt":0.2439035910750893,"score_spread":0.2201812401968546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}