{"id":"W3139798761","doi":"10.1016/j.ejphar.2008.01.056","title":"Rho kinase inhibitors: A novel therapeutical intervention in asthma?","year":2008,"lang":"en","type":"review","venue":"European Journal of Pharmacology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Manitoba; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"","keywords":"Bronchoconstriction; Asthma; Medicine; Airway; Airway hyperresponsiveness; Immunology; Ex vivo; Inflammation; Fibrosis; Airway obstruction; Extracellular matrix; In vivo; Pathology; Biology; Anesthesia; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009133396,0.0003025703,0.0007286457,0.000317743,0.00003947186,0.00001581143,0.0003458518,0.0001510646,0.00009379473],"category_scores_gemma":[0.0000580431,0.0002558085,0.0007065395,0.0001708685,0.0001053939,0.00000700937,0.0001401846,0.0005842862,0.00002796801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005745555,"about_ca_system_score_gemma":0.0001908936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.207291e-7,"about_ca_topic_score_gemma":6.954161e-7,"domain_scores_codex":[0.9968444,0.001336566,0.001145447,0.0002690853,0.0001535273,0.0002510112],"domain_scores_gemma":[0.9987494,0.00002695827,0.0008634325,0.0001299029,0.0001164169,0.0001138429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001302262,0.0004103965,0.000001668295,0.0007204419,0.0002697825,0.0008788918,0.00002898741,0.00002587798,0.02498537,0.0000112687,0.003266348,0.9692708],"study_design_scores_gemma":[0.001676714,0.0005110923,0.000007166423,0.001767335,0.0001257329,0.001676323,0.000005401115,0.000007885612,0.002192545,0.000001758943,0.9918036,0.0002243824],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005945987,0.9964839,0.001612817,0.00005058156,0.0007167046,0.0002628335,0.000009942216,0.000005104129,0.0002634873],"genre_scores_gemma":[0.003749986,0.9936325,0.0004277391,0.0001886232,0.00179829,0.000006038838,0.00004187646,0.00006715264,0.00008780017],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9885373,"threshold_uncertainty_score":0.9999894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03836646238415656,"score_gpt":0.3403082452038996,"score_spread":0.301941782819743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}