{"id":"W3140002833","doi":"10.1016/j.lfs.2021.119451","title":"Could gene therapy cure HIV?","year":2021,"lang":"en","type":"review","venue":"Life Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; London Health Sciences Centre","funders":"","keywords":"Medicine; Genetic enhancement; Intensive care medicine; Human immunodeficiency virus (HIV); Disease; Antiretroviral therapy; Pharmacotherapy; Immunology; Biology; Gene; Psychiatry; Viral load; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485713,0.0002721832,0.0005732912,0.00006144258,0.0001434093,0.00007689397,0.0007128539,0.0003019414,0.0001303956],"category_scores_gemma":[0.00005579242,0.0001918354,0.0003666478,0.0002675651,0.0002301348,0.000003936934,0.000154061,0.0001393065,0.0001005221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006434561,"about_ca_system_score_gemma":0.0008365061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006639331,"about_ca_topic_score_gemma":0.000003859894,"domain_scores_codex":[0.9984611,0.0001095193,0.0002854961,0.0006443686,0.0002206181,0.0002789267],"domain_scores_gemma":[0.9992788,0.00001651651,0.0001546779,0.0003809953,0.00006871868,0.0001002997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003959723,0.00006453519,0.00003507622,0.0004697518,0.0002078651,0.00001461165,0.00002489574,0.000005572775,0.0009944265,0.00006802727,0.09972468,0.8983866],"study_design_scores_gemma":[0.00005054295,0.0001454955,0.000001110786,0.0005816824,0.00003582139,0.00002573849,0.00002837707,0.000001488111,0.0009110918,0.000006489878,0.997954,0.0002581862],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002650447,0.9971928,0.00004784833,0.00007815546,0.000498367,0.0001565257,0.00004819984,0.000009023904,0.001704026],"genre_scores_gemma":[0.00003374155,0.9960338,0.0002203285,0.0005462421,0.000710356,0.0000336274,0.000225921,0.00001609206,0.002179841],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8982293,"threshold_uncertainty_score":0.7822821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09177286535263994,"score_gpt":0.3726625109641381,"score_spread":0.2808896456114982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}