{"id":"W3140002833","doi":"10.1016/j.lfs.2021.119451","title":"Could gene therapy cure HIV?","year":2021,"lang":"en","type":"review","venue":"Life Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; London Health Sciences Centre","funders":"","keywords":"Medicine; Genetic enhancement; Intensive care medicine; Human immunodeficiency virus (HIV); Disease; Antiretroviral therapy; Pharmacotherapy; Immunology; Biology; Gene; Psychiatry; Viral load; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009689785,0.001476055,0.001686995,0.001862844,0.0003808805,0.001378428,0.001089711,0.002265716,0.00481535],"category_scores_gemma":[0.001081554,0.0003372297,0.000455748,0.001586854,0.0009896641,0.00173954,0.0007950781,0.003838281,0.003794504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165296,"about_ca_system_score_gemma":0.00118436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001454257,"about_ca_topic_score_gemma":0.003718519,"domain_scores_codex":[0.9997926,0.0000460013,0.00001712457,0.00003073391,0.00008475585,0.00002876981],"domain_scores_gemma":[0.9997414,0.0001462446,0.00002271597,0.000009818795,0.00005158973,0.0000281313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001278968,0.00009960961,0.00006174929,0.008219616,0.0000478031,0.0001921742,0.00003855613,0.0003929936,0.002216783,0.01254328,0.1202577,0.8558019],"study_design_scores_gemma":[0.00003799982,0.00005319636,0.0001445106,0.001697047,0.00004446101,0.0004488249,0.00002527481,0.0000916656,0.0003832699,0.00363505,0.9934269,0.00001190461],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003685816,0.9962304,0.000240234,0.0007644039,0.000910953,0.000005065521,0.00001359227,0.00001264222,0.001785723],"genre_scores_gemma":[0.0003793422,0.9962664,0.0003137632,0.0007395584,0.0005346625,0.00001281805,0.00002329964,0.000003174318,0.001726924],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00481535,"threshold_uncertainty_score":0.01610893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09177286535263994,"score_gpt":0.3726625109641381,"score_spread":0.2808896456114982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}