{"id":"W3140056442","doi":"10.3389/fgene.2021.625246","title":"System-Level Analysis of Alzheimer’s Disease Prioritizes Candidate Genes for Neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; National Institute of General Medical Sciences; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Context (archaeology); Alzheimer's Disease Neuroimaging Initiative; Apolipoprotein E; Neuroscience; Disease; Candidate gene; Neurodegeneration; Genetic association; Neuroimaging; Brain Structure and Function; Biology; Alzheimer's disease; Bioinformatics; Medicine; Genetics; Gene; Single-nucleotide polymorphism; Genotype; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009041305,0.0001401447,0.0004507376,0.0003315309,0.00005477112,0.00001776129,0.00006392213,0.00005399505,0.00001087894],"category_scores_gemma":[0.00004933997,0.0001349835,0.0002324435,0.0006168638,0.00005573569,0.00003067061,0.00003447246,0.00004877585,0.000001200553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007406356,"about_ca_system_score_gemma":0.0004945031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002550236,"about_ca_topic_score_gemma":0.00004027211,"domain_scores_codex":[0.9986888,0.00007433508,0.0003300433,0.0003242074,0.0003160368,0.0002666073],"domain_scores_gemma":[0.9989322,0.00002237749,0.00007850855,0.0003958557,0.0002815887,0.0002894631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006118526,0.0005148441,0.9550751,0.0003597892,0.02754545,0.000307465,0.00008062353,0.002049062,0.0007894671,0.0001090865,0.002260122,0.01029716],"study_design_scores_gemma":[0.004066709,0.0002434301,0.7960897,0.0001313906,0.03472506,0.000005619946,0.0004342853,0.129641,0.03358728,0.0001014635,0.0006591011,0.0003150072],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8028629,0.1757733,0.01779081,0.0002603045,0.0005253813,0.001086602,0.001556678,0.00003241288,0.0001116863],"genre_scores_gemma":[0.9728273,0.001982708,0.02373626,0.00004554364,0.00008088713,0.00009865559,0.0011401,0.00002497138,0.00006359324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1737906,"threshold_uncertainty_score":0.5504469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03966328834308247,"score_gpt":0.3142369598408085,"score_spread":0.274573671497726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}