{"id":"W3140056442","doi":"10.3389/fgene.2021.625246","title":"System-Level Analysis of Alzheimer’s Disease Prioritizes Candidate Genes for Neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; National Institute of General Medical Sciences; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Context (archaeology); Alzheimer's Disease Neuroimaging Initiative; Apolipoprotein E; Neuroscience; Disease; Candidate gene; Neurodegeneration; Genetic association; Neuroimaging; Brain Structure and Function; Biology; Alzheimer's disease; Bioinformatics; Medicine; Genetics; Gene; Single-nucleotide polymorphism; Genotype; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002600762,0.0009868603,0.001292627,0.002996202,0.0006702547,0.001463805,0.0009216663,0.0006606609,0.003127363],"category_scores_gemma":[0.005550941,0.0002540667,0.002125201,0.001393358,0.0005251469,0.0005326487,0.001153765,0.0009250182,0.0006859681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007788564,"about_ca_system_score_gemma":0.001522564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004634704,"about_ca_topic_score_gemma":0.006509069,"domain_scores_codex":[0.9987465,0.0003220717,0.000082721,0.0003659718,0.0003224583,0.0001602205],"domain_scores_gemma":[0.9969313,0.001861024,0.0002717984,0.000239823,0.0005192265,0.0001768353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001873593,0.0006221066,0.3824847,0.0008042278,0.002271175,0.00141104,0.0003858112,0.123572,0.0961993,0.009933842,0.00652366,0.3739185],"study_design_scores_gemma":[0.0001701291,0.0007595842,0.1109907,0.00003899602,0.0007071014,0.0005011281,0.0001180147,0.8454601,0.01729667,0.02050565,0.003380421,0.00007151838],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5202551,0.001444412,0.467177,0.000965143,0.0001044201,0.0003140132,0.002150016,0.004289815,0.003299923],"genre_scores_gemma":[0.8957253,0.0001913638,0.09929857,0.0002134312,0.00007105671,0.0001397103,0.002333907,0.0002106287,0.001816043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004634704,"threshold_uncertainty_score":0.01375431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03966328834308247,"score_gpt":0.3142369598408085,"score_spread":0.274573671497726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}