{"id":"W3140079447","doi":"10.1158/1538-7445.am2013-sy05-01","title":"Abstract SY05-01: Genetic and non-genetic mechanisms contribute to long-term clonal growth dynamics and therapy resistance.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Cancer stem cell; Biology; Somatic evolution in cancer; Genetic heterogeneity; Stem cell; Epigenetics; Cancer; Cancer research; Genetics; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004871322,0.0003630254,0.0003962022,0.0006545176,0.0003700464,0.001178006,0.0004333993,0.0006870182,0.008840483],"category_scores_gemma":[0.0005007457,0.0001997276,0.000342477,0.0003339005,0.0005114931,0.0003768852,0.0005163011,0.001078528,0.002787641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006354804,"about_ca_system_score_gemma":0.0004312203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005153973,"about_ca_topic_score_gemma":0.0004327967,"domain_scores_codex":[0.9995968,0.00007740189,0.00003554317,0.00007399424,0.0001345878,0.00008181329],"domain_scores_gemma":[0.9994875,0.0001250103,0.0001316106,0.00006304216,0.00006152098,0.000131212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001098119,0.0005282079,0.007276402,0.00019902,0.00004522228,0.0004873853,0.00008150769,0.0004590423,0.946668,0.003563214,0.00586953,0.03372425],"study_design_scores_gemma":[0.0003494658,0.00582552,0.09100877,0.0001184018,0.0001888216,0.005560667,0.0003597809,0.01407375,0.8236619,0.002671953,0.0561372,0.00004385478],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719464,0.005550125,0.004028384,0.000802612,0.000253678,0.0001462198,0.002486353,0.0006130239,0.01417322],"genre_scores_gemma":[0.9833705,0.0008189889,0.001122781,0.0003117717,0.00004347728,0.00007567099,0.003522423,0.00008823925,0.01064614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008840483,"threshold_uncertainty_score":0.02957433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675921779556641,"score_gpt":0.3098274240946527,"score_spread":0.2930682062990863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}