{"id":"W3140088470","doi":"10.1038/nmeth.4559","title":"Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”","year":2018,"lang":"en","type":"letter","venue":"Nature Methods","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Toronto Centre for Phenogenomics; Hospital for Sick Children","funders":"National Institutes of Health; Genome Canada","keywords":"CRISPR; Genome editing; Biology; Genetics; Computational biology; In vivo; Cas9; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004300468,0.001111304,0.0009378756,0.0005167287,0.003546241,0.003632492,0.00179013,0.04311363,0.005418528],"category_scores_gemma":[0.02139121,0.0007628353,0.00128269,0.0003694887,0.003004182,0.00225983,0.001798521,0.03764766,0.004567404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004489018,"about_ca_system_score_gemma":0.002145683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001335592,"about_ca_topic_score_gemma":0.001965648,"domain_scores_codex":[0.9965895,0.0005880772,0.0002937808,0.0005109371,0.001343091,0.0006746188],"domain_scores_gemma":[0.9940507,0.003293953,0.0005037785,0.0002552535,0.001022044,0.0008742845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009656374,0.00003505308,0.000259084,0.00003589881,0.00002036493,0.002139406,0.00008838291,0.0001011202,0.0009518528,0.003339277,0.9852129,0.007720074],"study_design_scores_gemma":[0.0002879039,0.00018894,0.0009741447,0.0001560513,0.00006387302,0.003757882,0.0003125519,0.001258778,0.003641012,0.01474498,0.9745198,0.00009408122],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0008931502,0.0009884842,0.0006416056,0.9593274,0.03485259,0.00002034741,0.00009731287,0.0001399589,0.003039217],"genre_scores_gemma":[0.007552935,0.0007809593,0.0006275807,0.9563448,0.02534576,0.00007616955,0.00006547229,0.00005531584,0.009151014],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04311363,"threshold_uncertainty_score":0.03257024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008265518748828115,"score_gpt":0.3940686728648473,"score_spread":0.3858031541160192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}