{"id":"W3140304988","doi":"10.1128/mbio.03328-20","title":"Balancing Positive and Negative Selection: <i>In Vivo</i> Evolution of Candida lusitaniae <i>MRR1</i>","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institute for Advanced Research; NIH Office of the Director; National Heart, Lung, and Blood Institute; Dartmouth College; National Institute of General Medical Sciences; National Cancer Institute; National Science Foundation; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Biology; Microbiology; Pathogen; Selection (genetic algorithm); Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223286,0.00007615531,0.0002204701,0.00003615575,0.00004571056,0.000005774871,0.00001638119,0.00006080859,0.00009706539],"category_scores_gemma":[0.0001354655,0.00007300457,0.00003952343,0.0003065954,0.000062678,0.00006231933,0.00002035307,0.0001178276,0.000002404783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000204481,"about_ca_system_score_gemma":0.0002049828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007539209,"about_ca_topic_score_gemma":0.003752823,"domain_scores_codex":[0.9993116,0.00003479919,0.0001688079,0.0002111406,0.0001355299,0.0001381438],"domain_scores_gemma":[0.9995834,0.00006988647,0.00004066523,0.00008343114,0.0001694015,0.0000532729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002158988,0.00008689093,0.6902213,0.00008645501,0.00002449159,0.0000471802,0.0005196705,0.000001124224,0.3073865,0.0004777343,0.0004879817,0.0004448313],"study_design_scores_gemma":[0.000924815,0.0001477677,0.8241329,0.0002203951,0.00003919082,0.00004659891,0.001159096,0.0001211415,0.1725833,0.0003093345,0.0002338813,0.00008155085],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906127,0.0009498819,0.000289112,0.0002675713,0.00004424798,0.0001241013,0.00001957475,0.0000127175,0.007680134],"genre_scores_gemma":[0.9982607,0.00006058269,0.0004078925,0.000188103,0.00004237487,0.000002645416,0.000003440211,0.000006042098,0.001028244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1348031,"threshold_uncertainty_score":0.297704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004939487685769462,"score_gpt":0.2352397192415522,"score_spread":0.2303002315557827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}