{"id":"W3140304988","doi":"10.1128/mbio.03328-20","title":"Balancing Positive and Negative Selection: <i>In Vivo</i> Evolution of Candida lusitaniae <i>MRR1</i>","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institute for Advanced Research; NIH Office of the Director; National Heart, Lung, and Blood Institute; Dartmouth College; National Institute of General Medical Sciences; National Cancer Institute; National Science Foundation; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Biology; Microbiology; Pathogen; Selection (genetic algorithm); Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003137825,0.000296862,0.0002270984,0.0002065085,0.0001876517,0.0005429428,0.0003189286,0.0003358966,0.001338672],"category_scores_gemma":[0.0003924134,0.0001099656,0.0001932565,0.0001499239,0.0003733707,0.0002629554,0.00035951,0.0007638162,0.0003174598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004014703,"about_ca_system_score_gemma":0.0001754169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005732144,"about_ca_topic_score_gemma":0.0009997411,"domain_scores_codex":[0.9997796,0.00005164989,0.00001173293,0.00006468606,0.00003645294,0.00005589225],"domain_scores_gemma":[0.999724,0.00007171354,0.00008986499,0.00004291668,0.00001884903,0.00005275182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001820604,0.00002448432,0.002936225,0.00001726669,0.000008025324,0.00005429427,0.00003431734,0.0001853855,0.9924279,0.0003560564,0.00005489431,0.003719018],"study_design_scores_gemma":[0.00003407739,0.00115892,0.09666919,0.00002795265,0.00005791488,0.002285918,0.0003091887,0.009700907,0.8819571,0.0006495373,0.007091726,0.00005754776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945187,0.000427825,0.002714801,0.0001609456,0.00001844231,0.00001038867,0.0002208819,0.00004810746,0.00187984],"genre_scores_gemma":[0.99733,0.0001582791,0.001366937,0.00006575127,0.00000734694,0.00000824187,0.0002039493,0.00002725019,0.0008322868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338672,"threshold_uncertainty_score":0.004478276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004939487685769462,"score_gpt":0.2352397192415522,"score_spread":0.2303002315557827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}