{"id":"W3140545115","doi":"10.3390/toxins13040235","title":"Tetrodotoxin for Chemotherapy-Induced Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Dose Finding Trial","year":2021,"lang":"en","type":"article","venue":"Toxins","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Placebo; Medicine; Neuropathic pain; Anesthesia; Adverse effect; Randomized controlled trial; Cohort; Pregabalin; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00211762,0.001428951,0.003235097,0.0005760119,0.0005365044,0.001003733,0.000970312,0.002238606,0.004784927],"category_scores_gemma":[0.001863765,0.0007621501,0.001407641,0.0004892395,0.001340553,0.001060249,0.0003649486,0.002163583,0.00088492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006527838,"about_ca_system_score_gemma":0.001100678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005088513,"about_ca_topic_score_gemma":0.001293802,"domain_scores_codex":[0.9991416,0.0004154986,0.00007983798,0.0001639193,0.00009056764,0.0001086277],"domain_scores_gemma":[0.9990475,0.0002379577,0.0002786843,0.00008901945,0.00009947158,0.000247385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9698792,0.01160384,0.0002661799,0.0006966828,0.0004452821,0.00003871224,0.00003717569,0.000153657,0.004892627,0.00008985753,0.0003975722,0.01149932],"study_design_scores_gemma":[0.9385692,0.06011727,0.0004549494,0.00001894853,0.0001408938,0.00001588267,0.000007259712,0.000145189,0.0002492378,0.00004416657,0.0002297106,0.00000722289],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808139,0.005363172,0.001132858,0.0006850946,0.0009085758,0.008847184,0.0007061724,0.0001589976,0.001384031],"genre_scores_gemma":[0.9723355,0.005222361,0.002969655,0.001542427,0.0009026206,0.01204645,0.0008047739,0.00003587961,0.004140382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004784927,"threshold_uncertainty_score":0.01600713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0721859294665846,"score_gpt":0.3582472610767269,"score_spread":0.2860613316101424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}