{"id":"W3140545115","doi":"10.3390/toxins13040235","title":"Tetrodotoxin for Chemotherapy-Induced Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Dose Finding Trial","year":2021,"lang":"en","type":"article","venue":"Toxins","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Placebo; Medicine; Neuropathic pain; Anesthesia; Adverse effect; Randomized controlled trial; Cohort; Pregabalin; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003049425,0.0003418175,0.001534607,0.0001545623,0.0001622598,0.00005101015,0.0001114401,0.0002030387,0.001168459],"category_scores_gemma":[0.0009916571,0.0002731803,0.0008300558,0.0002543486,0.0000643091,0.00006661074,0.00003072534,0.0003134609,0.00004427668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490933,"about_ca_system_score_gemma":0.0004806639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002835849,"about_ca_topic_score_gemma":0.0000464065,"domain_scores_codex":[0.9972091,0.0008670866,0.0006230247,0.0005298736,0.0002600225,0.0005108505],"domain_scores_gemma":[0.9964816,0.002585182,0.0002164435,0.000350563,0.0001475582,0.0002186442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9652771,0.0009150211,0.00002777243,0.00006984523,0.0008591321,0.0001705509,0.0003971189,0.0000111645,0.0225514,0.000238969,0.003012722,0.0064692],"study_design_scores_gemma":[0.9698122,0.001199965,0.000004762549,0.00004458304,0.0009544166,0.0000553287,0.00006375197,0.001727441,0.01215678,0.0001051289,0.01363671,0.0002388964],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602735,0.001168859,0.00297844,0.01173792,0.001961222,0.01582013,0.00002076572,0.0002180695,0.005821091],"genre_scores_gemma":[0.9731266,0.0002892639,0.0008492924,0.004469865,0.00224764,0.004422163,0.0001225385,0.0000756493,0.014397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01285308,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0721859294665846,"score_gpt":0.3582472610767269,"score_spread":0.2860613316101424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}