{"id":"W3140552430","doi":"10.1371/journal.ppat.1009476","title":"Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Toronto; University of British Columbia","funders":"Helse Sør-Øst RHF; National Health and Medical Research Council; CH.I.L.D. Foundation; Crohn's and Colitis Canada; Norges Forskningsråd; Medical Research Council; H2020 Marie Skłodowska-Curie Actions; Kreftforeningen","keywords":"Goblet cell; Biology; Intestinal epithelium; Effector; Immunology; Reprogramming; Intestinal mucosa; Immunity; Cell biology; Inflammation; Immune system; Histone; Epithelium; Cell; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330232,0.0001275161,0.0001486247,0.0000369453,0.0001209771,0.00006544905,0.00003194631,0.0001165538,0.00000638823],"category_scores_gemma":[0.0008890183,0.000128372,0.00004327734,0.00005230049,0.00002914545,0.000005982666,0.00007426101,0.000047547,0.000002606719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001167094,"about_ca_system_score_gemma":0.00004922489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001236513,"about_ca_topic_score_gemma":0.00004581868,"domain_scores_codex":[0.9991354,0.0001912823,0.0001733157,0.0002839119,0.00006624147,0.0001498768],"domain_scores_gemma":[0.9993731,0.0001069428,0.00007007208,0.0001857584,0.0001811799,0.00008292502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007472011,0.00005389521,0.002355002,0.00005450354,0.00001965678,0.000001840862,0.00006901569,0.000005239169,0.9946619,0.000008861395,0.0000258902,0.001997024],"study_design_scores_gemma":[0.0008548867,0.0008066263,0.03175933,0.0000241505,0.00005382315,0.000005954382,0.00001496376,0.0001035202,0.962231,0.0000825561,0.00390998,0.0001532208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932627,0.0004500827,0.005267526,0.0001000245,0.0001712115,0.0004325304,0.0002502504,0.00001139925,0.00005423734],"genre_scores_gemma":[0.9951878,0.0002397678,0.003499434,0.00006664262,0.0003386624,0.00007740557,0.0004121374,0.00001982595,0.0001582935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03243088,"threshold_uncertainty_score":0.5234858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01621499833721671,"score_gpt":0.2581619501484576,"score_spread":0.2419469518112409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}