{"id":"W3140552430","doi":"10.1371/journal.ppat.1009476","title":"Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Toronto; University of British Columbia","funders":"Helse Sør-Øst RHF; National Health and Medical Research Council; CH.I.L.D. Foundation; Crohn's and Colitis Canada; Norges Forskningsråd; Medical Research Council; H2020 Marie Skłodowska-Curie Actions; Kreftforeningen","keywords":"Goblet cell; Biology; Intestinal epithelium; Effector; Immunology; Reprogramming; Intestinal mucosa; Immunity; Cell biology; Inflammation; Immune system; Histone; Epithelium; Cell; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381267,0.0002053136,0.0002163167,0.0002793616,0.0001647159,0.0003641357,0.000200692,0.0002988196,0.001320013],"category_scores_gemma":[0.0001311233,0.0001522345,0.0001963091,0.00008403498,0.0004008227,0.0002159428,0.0003327517,0.0004152253,0.0003455848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002987803,"about_ca_system_score_gemma":0.0002093101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004320413,"about_ca_topic_score_gemma":0.0009652973,"domain_scores_codex":[0.9998627,0.00001997474,0.0000123577,0.00003353275,0.00002238159,0.00004897446],"domain_scores_gemma":[0.9998351,0.00001288127,0.00006328737,0.00001574794,0.00001108396,0.00006186544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002121981,0.00001262189,0.0009112577,0.00002936904,0.000002376266,0.0000492181,0.00001668413,0.00004702985,0.9978028,0.0001474575,0.00002882782,0.0007400896],"study_design_scores_gemma":[0.00003610764,0.0002371148,0.03655789,0.00001398135,0.00002052554,0.0003306799,0.0001403306,0.0009431053,0.959168,0.000180323,0.002361354,0.00001044769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960458,0.0009324802,0.00150956,0.0001032321,0.00001704118,0.000009410743,0.0003063271,0.0001145873,0.0009615134],"genre_scores_gemma":[0.9974204,0.0002425587,0.0006009704,0.00002834077,0.000003148107,0.00001003852,0.000157344,0.00001801961,0.001519152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320013,"threshold_uncertainty_score":0.00441587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01621499833721671,"score_gpt":0.2581619501484576,"score_spread":0.2419469518112409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}