{"id":"W3140555419","doi":"10.1111/bcp.14850","title":"Randomised, phase I pharmacokinetic study of adalimumab biosimilar CT‐P17 (40 mg/0.4 mL) by autoinjector and prefilled syringe in healthy subjects","year":2021,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Celltrion","keywords":"Pharmacokinetics; Medicine; Confidence interval; Area under the curve; Bioequivalence; Nuclear medicine; Urology; Gastroenterology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003947508,0.0002924217,0.002104226,0.0001845755,0.0001147326,0.00002550473,0.000380425,0.0003372869,0.001820253],"category_scores_gemma":[0.001545521,0.0002861289,0.0003885323,0.0003735165,0.0005543781,0.0001211313,0.0001997774,0.001756952,0.00000454377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004530991,"about_ca_system_score_gemma":0.0003807255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006687987,"about_ca_topic_score_gemma":0.00006062235,"domain_scores_codex":[0.9908658,0.00466927,0.003179885,0.0005582168,0.0001457677,0.0005811073],"domain_scores_gemma":[0.9950786,0.002952584,0.001187191,0.0001703003,0.0003825661,0.0002287232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1142365,0.04324322,0.01094994,0.0003902542,0.004698572,0.009568861,0.0003587238,0.00002097806,0.49056,0.000008495125,0.1015707,0.2243937],"study_design_scores_gemma":[0.7583649,0.02157126,0.02415777,0.000501309,0.002976614,0.01074445,0.0009113984,0.0002201876,0.1146608,0.0001504252,0.06473719,0.001003685],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629112,0.0319028,0.00003552084,0.001269342,0.00297975,0.0006472856,0.0000948176,0.00001623164,0.0001430836],"genre_scores_gemma":[0.9852521,0.01135034,0.0002981085,0.002614294,0.0002453261,0.00001581795,0.000009191742,0.00002952232,0.000185307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6441284,"threshold_uncertainty_score":0.9999591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04880752646326203,"score_gpt":0.422739270623926,"score_spread":0.3739317441606639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}