{"id":"W3140555419","doi":"10.1111/bcp.14850","title":"Randomised, phase I pharmacokinetic study of adalimumab biosimilar CT‐P17 (40 mg/0.4 mL) by autoinjector and prefilled syringe in healthy subjects","year":2021,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Celltrion","keywords":"Pharmacokinetics; Medicine; Confidence interval; Area under the curve; Bioequivalence; Nuclear medicine; Urology; Gastroenterology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003955214,0.001513164,0.002804616,0.0004476744,0.0004723825,0.0008755765,0.0008296118,0.001492326,0.00550342],"category_scores_gemma":[0.003121722,0.001081523,0.001286622,0.0004803739,0.001780674,0.001190058,0.0004794057,0.002474528,0.001148315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008126817,"about_ca_system_score_gemma":0.002069373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006487654,"about_ca_topic_score_gemma":0.0008237758,"domain_scores_codex":[0.9982456,0.0009964245,0.00009308877,0.0003044391,0.0001702775,0.0001902549],"domain_scores_gemma":[0.9981884,0.0004502966,0.0004030482,0.0002712425,0.0001646032,0.0005224198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9357972,0.02906715,0.0009720126,0.0002709394,0.0003645122,0.0000582701,0.0001594006,0.0004408636,0.01722868,0.0001905099,0.0006768074,0.0147736],"study_design_scores_gemma":[0.5430103,0.4505779,0.002180495,0.0000140241,0.0002387681,0.00006489666,0.00003529912,0.0005138502,0.002182272,0.0001847874,0.0009735549,0.00002386522],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844897,0.0008009795,0.002501968,0.0001541349,0.0002964874,0.009987116,0.0007367778,0.00009117978,0.0009416574],"genre_scores_gemma":[0.9824288,0.0006745887,0.003821809,0.0006484005,0.0004331191,0.008420425,0.0007228809,0.00003632467,0.002813707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00550342,"threshold_uncertainty_score":0.02091742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04880752646326203,"score_gpt":0.422739270623926,"score_spread":0.3739317441606639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}