{"id":"W3140564387","doi":"10.1016/j.micinf.2021.104814","title":"Direct and indirect effects of microbiota-derived metabolites on neuroinflammation in multiple sclerosis","year":2021,"lang":"en","type":"review","venue":"Microbes and Infection","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Institute of Infection and Immunity; Canadian Institutes of Health Research; Multiple Sclerosis Society","keywords":"Neuroinflammation; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Immune system; Biology; Encephalomyelitis; Immunology; Central nervous system; Neuroscience; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001551951,0.0003043747,0.0008894873,0.0002084508,0.00007234032,0.00003642953,0.00004420604,0.0003484882,0.000003111988],"category_scores_gemma":[0.0001039125,0.00027452,0.0001714307,0.0001782108,0.00006148557,0.000006305098,0.00009032347,0.0001585808,0.000001818305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002246601,"about_ca_system_score_gemma":0.00006797797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001498794,"about_ca_topic_score_gemma":0.0001512245,"domain_scores_codex":[0.9986368,0.0002628801,0.000394483,0.0004723759,0.00003725621,0.0001962353],"domain_scores_gemma":[0.9994025,0.00007254411,0.0002405134,0.0001970668,0.00004040539,0.00004693907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008517995,0.00006670539,0.0002546578,0.007161008,0.00006363011,0.000001125848,0.00002842526,6.493043e-7,0.8031576,0.000003049993,0.00009944046,0.1891552],"study_design_scores_gemma":[0.0006849428,0.0003327438,0.007999402,0.00802025,0.0002844227,0.00004674122,0.000004023968,0.000001123273,0.4427699,8.747142e-7,0.5394648,0.0003907566],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3339761,0.6654348,0.000004952809,0.000003256519,0.0001275957,0.0003941531,0.00002538086,0.000006346126,0.00002737645],"genre_scores_gemma":[0.01738396,0.981981,0.00007357064,0.00002757976,0.00007757646,0.00003054686,0.0003494738,0.00003371475,0.00004257299],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5393654,"threshold_uncertainty_score":0.9999707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02624878786045128,"score_gpt":0.2615451205081016,"score_spread":0.2352963326476503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}