{"id":"W3140573993","doi":"10.3389/fmolb.2021.611367","title":"A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Vancouver General Hospital; University of British Columbia; Vancouver Coastal Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Urology Foundation; University of British Columbia; W. Garfield Weston Foundation; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC; University of Victoria","keywords":"Neuroinflammation; NOX4; Gene knockdown; Blood–brain barrier; Small interfering RNA; Oxidative stress; Pharmacology; Central nervous system; Medicine; Transcytosis; Chemistry; Cell biology; Neuroscience; Biology; Inflammation; Immunology; Biochemistry; Internal medicine; NADPH oxidase; Receptor; Gene; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723323,0.0003019238,0.000284735,0.0002238422,0.0001356207,0.0002352652,0.0002356305,0.0003987618,0.000645928],"category_scores_gemma":[0.0001233891,0.0001060821,0.0001315604,0.00008933178,0.00021928,0.0002917937,0.0001699038,0.0003879614,0.0002379752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002509766,"about_ca_system_score_gemma":0.0002494903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002822412,"about_ca_topic_score_gemma":0.0004035781,"domain_scores_codex":[0.9999206,0.00001133635,0.000006850441,0.00002253793,0.00002339639,0.00001530838],"domain_scores_gemma":[0.9999567,0.000008091992,0.00001352577,0.000003368769,0.000007424581,0.0000110082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003609195,0.00003198814,0.00002331223,0.0000387516,0.000002755088,0.00002269573,0.00000760425,0.0001024527,0.9976549,0.0001530179,0.00003305234,0.001893431],"study_design_scores_gemma":[0.00002673181,0.0007279277,0.0005093883,0.000005110923,0.00001437476,0.0001685558,0.000005739858,0.001329007,0.9947431,0.00005751176,0.002406912,0.000005758511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693034,0.002688273,0.02496098,0.0003085699,0.0001103084,0.0001637935,0.0001462643,0.0001991231,0.002119152],"genre_scores_gemma":[0.9756806,0.001342464,0.01991224,0.0001121527,0.00002998278,0.0001482568,0.0001451474,0.00002529447,0.00260397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000645928,"threshold_uncertainty_score":0.002160847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005865823176509534,"score_gpt":0.2435794296608222,"score_spread":0.2377136064843127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}