{"id":"W3140573993","doi":"10.3389/fmolb.2021.611367","title":"A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Vancouver General Hospital; University of British Columbia; Vancouver Coastal Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Urology Foundation; University of British Columbia; W. Garfield Weston Foundation; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC; University of Victoria","keywords":"Neuroinflammation; NOX4; Gene knockdown; Blood–brain barrier; Small interfering RNA; Oxidative stress; Pharmacology; Central nervous system; Medicine; Transcytosis; Chemistry; Cell biology; Neuroscience; Biology; Inflammation; Immunology; Biochemistry; Internal medicine; NADPH oxidase; Receptor; Gene; Transfection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004502925,0.0002619425,0.0002263326,0.00008007292,0.0002254506,0.0001478572,0.000829518,0.0001602503,0.00002246133],"category_scores_gemma":[0.0003576993,0.0002109282,0.0001901797,0.0004842256,0.00033623,0.00001753686,0.0004211857,0.0001847099,0.00001249144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003111953,"about_ca_system_score_gemma":0.0002523189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008941631,"about_ca_topic_score_gemma":0.0002210419,"domain_scores_codex":[0.9977688,0.0001533041,0.000292335,0.0008007918,0.0003451616,0.0006396743],"domain_scores_gemma":[0.9989591,0.00001415972,0.00008077985,0.0006194252,0.0001444073,0.0001821358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003599506,0.00003347104,0.01347872,0.000005597997,0.000064498,0.00008362116,0.0004338869,0.0002748464,0.9642223,0.000006872896,0.0198126,0.00154764],"study_design_scores_gemma":[0.0003756555,0.0001997069,0.001353148,0.00002852518,0.00002225765,0.00002905689,0.004253995,0.0001490937,0.9287189,0.00002386894,0.06451023,0.0003355306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888091,0.001822891,0.005941859,0.001305525,0.0007920644,0.0002094435,0.0001223549,0.00001081067,0.0009859506],"genre_scores_gemma":[0.9865057,0.0001715766,0.004175914,0.004623425,0.00009636711,0.00004227551,0.00003920928,0.0000225863,0.004322939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04469763,"threshold_uncertainty_score":0.8601403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005865823176509534,"score_gpt":0.2435794296608222,"score_spread":0.2377136064843127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}