{"id":"W3140839780","doi":"10.1101/2021.04.02.438217","title":"HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Office of Science; Genentech; Innovative Medicines Initiative; Ontario Genomics Institute; Frederick National Laboratory for Cancer Research; Wellcome Trust; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Huntington Society of Canada; National Institutes of Health; Ontario Genomics; Genome Canada; CHDI Foundation; Bayer; Pfizer; Argonne National Laboratory; U.S. Department of Energy","keywords":"Huntingtin; Polyglutamine tract; Exon; Huntingtin Protein; Mutant; Wild type; Trinucleotide repeat expansion; Biology; Chemistry; Cell biology; Biophysics; Genetics; Gene; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004974517,0.0001565353,0.00009700212,0.00006954657,0.0001397015,0.0002202444,0.0001006029,0.0001492354,0.001282952],"category_scores_gemma":[0.00006470879,0.00008005716,0.0000763307,0.00005011327,0.0001320173,0.0001313023,0.0001904914,0.0001615475,0.0003916186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001486226,"about_ca_system_score_gemma":0.00006897316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003935311,"about_ca_topic_score_gemma":0.0005568853,"domain_scores_codex":[0.99997,0.00000320863,9.512802e-7,0.000008258299,0.000009778153,0.000007887432],"domain_scores_gemma":[0.999975,0.00000426238,0.000006280482,0.000002016807,0.000003789253,0.00000860074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004658556,0.00000643673,0.0004762009,0.00001188373,0.000002316962,0.0000620452,0.00002506322,0.00009235577,0.9986118,0.000101073,0.00006589294,0.0004984292],"study_design_scores_gemma":[0.00001339287,0.0001070926,0.04958777,0.000008368977,0.00001059776,0.0005300305,0.0001716358,0.01128303,0.9352725,0.0004534638,0.002551216,0.00001088757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984218,0.0001577708,0.0007466733,0.00002383026,0.000003943031,0.000002169194,0.00006253977,0.00002632135,0.0005549872],"genre_scores_gemma":[0.9983643,0.0000697672,0.000626556,0.00001261388,0.000001835525,0.000003346348,0.0001737268,0.00001230433,0.0007355885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001282952,"threshold_uncertainty_score":0.004291952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0241314510518712,"score_gpt":0.2434239947914474,"score_spread":0.2192925437395762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}