{"id":"W3140852949","doi":"10.1016/j.cmet.2021.03.021","title":"Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective","year":2021,"lang":"en","type":"review","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Breakthrough T1D Canada; National Institute of Diabetes and Digestive and Kidney Diseases; Juvenile Diabetes Research Foundation United States of America","keywords":"Regenerative medicine; Induced pluripotent stem cell; Stem cell; Cell therapy; Medicine; Transplantation; Diabetes mellitus; Insulin; Beta cell; Clinical trial; Cell; Bioinformatics; Islet; Cancer research; Immunology; Biology; Embryonic stem cell; Internal medicine; Cell biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009102577,0.001043358,0.001552593,0.001907393,0.0001949179,0.001273289,0.00103931,0.001382635,0.00377678],"category_scores_gemma":[0.0008138829,0.0002686009,0.0005458174,0.002164961,0.0005236864,0.001763843,0.0007152673,0.002748798,0.002110584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005287162,"about_ca_system_score_gemma":0.0008071216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006635851,"about_ca_topic_score_gemma":0.001335806,"domain_scores_codex":[0.9998494,0.0000258683,0.00002150751,0.00002514408,0.00006285196,0.00001531089],"domain_scores_gemma":[0.999584,0.0002407547,0.00004108517,0.000009445488,0.00008580893,0.0000388767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001381817,0.000096368,0.0001217288,0.01757837,0.0001018775,0.0002200018,0.00003861131,0.000422209,0.003625094,0.008992879,0.0369967,0.931668],"study_design_scores_gemma":[0.00003301388,0.000122711,0.0004897281,0.003926298,0.0001475473,0.0008055707,0.00004630905,0.0001007364,0.000652699,0.003583021,0.9900704,0.00002210237],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004352563,0.9986281,0.0001395389,0.000302983,0.0002950319,0.000002108805,0.00001516609,0.000005353231,0.0005681055],"genre_scores_gemma":[0.0002583111,0.9987679,0.0001496051,0.0002367699,0.0002387398,0.000002904439,0.00002129854,8.222332e-7,0.000323584],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00377678,"threshold_uncertainty_score":0.01263463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05575139126339851,"score_gpt":0.3217168310554014,"score_spread":0.2659654397920029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}