{"id":"W3141008635","doi":"10.1002/stem.3382","title":"Fluid Shear Stress Promotes Embryonic Stem Cell Pluripotency via Interplay Between β-Catenin and Vinculin in Bioreactor Culture","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Embryonic stem cell; Catenin; Vinculin; Cell biology; Stem cell; Bioreactor; Cell culture; Beta-catenin; Shear stress; Wnt signaling pathway; Genetics; Botany; Signal transduction; Gene; Focal adhesion; Mechanics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003197117,0.0003902344,0.0004346949,0.0001153004,0.00009258114,0.0001030167,0.0004074756,0.0004347458,0.00005292446],"category_scores_gemma":[0.000007723477,0.0003571884,0.0001418001,0.0002852617,0.0001212914,0.00001693837,0.0005570401,0.0003791221,0.0001192654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000604553,"about_ca_system_score_gemma":0.0001696818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003914231,"about_ca_topic_score_gemma":0.00005774205,"domain_scores_codex":[0.9971972,0.0003046694,0.0004604514,0.0009885778,0.0003549019,0.0006942452],"domain_scores_gemma":[0.9988104,0.00003301175,0.0001213285,0.0005959012,0.0001642682,0.0002750912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003951907,0.0001447229,0.004880927,0.0003030506,0.00005944184,0.0001155772,0.0002548837,0.00001352298,0.9901099,0.000002689518,0.0007714273,0.003304384],"study_design_scores_gemma":[0.0008927942,0.0002930549,0.001318729,0.0001219283,0.00002725505,0.00002343846,0.0003693479,0.0001129939,0.98847,0.000009676268,0.007950851,0.000409929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912856,0.006159389,0.0002749876,0.0001453123,0.0001755763,0.0005268397,0.0002188734,0.00002430622,0.001189086],"genre_scores_gemma":[0.9847286,0.0009503885,0.000282152,0.00004415238,0.000200733,0.00003270855,0.0002489862,0.00005948816,0.01345275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01226366,"threshold_uncertainty_score":0.999888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003345708423224,"score_gpt":0.2548664682246158,"score_spread":0.2448330111403835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}