{"id":"W3141008635","doi":"10.1002/stem.3382","title":"Fluid Shear Stress Promotes Embryonic Stem Cell Pluripotency via Interplay Between β-Catenin and Vinculin in Bioreactor Culture","year":2021,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Embryonic stem cell; Catenin; Vinculin; Cell biology; Stem cell; Bioreactor; Cell culture; Beta-catenin; Shear stress; Wnt signaling pathway; Genetics; Botany; Signal transduction; Gene; Focal adhesion; Mechanics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347903,0.0002665404,0.0001707404,0.0001879911,0.0001356334,0.0003035881,0.0001419647,0.0001634345,0.0005813606],"category_scores_gemma":[0.00007401876,0.0001355848,0.0002039688,0.0001054495,0.0001357764,0.0001860588,0.0002033624,0.0003103317,0.0001331729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003288262,"about_ca_system_score_gemma":0.0001383851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000840559,"about_ca_topic_score_gemma":0.00134333,"domain_scores_codex":[0.999874,0.00002084523,0.00001569178,0.00002590031,0.00003969664,0.00002385311],"domain_scores_gemma":[0.9999502,0.000008196465,0.00001838098,0.000003848375,0.000006456467,0.00001304625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002559732,0.000007903323,0.0001276532,0.00001404836,0.000001935993,0.00001949056,0.000009764748,0.0000452281,0.9991973,0.00003363081,0.00001228613,0.0005051687],"study_design_scores_gemma":[0.000006149889,0.000114331,0.004095154,0.000005325809,0.000008891509,0.00005766538,0.00001927719,0.001277347,0.9933923,0.00003371489,0.0009857968,0.000004122277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934033,0.001867699,0.003351987,0.00008262095,0.0000338158,0.00002063514,0.0001161958,0.00003728073,0.001086575],"genre_scores_gemma":[0.9957689,0.000757343,0.002035619,0.00004277694,0.00001442743,0.00002817983,0.0001824308,0.000009750417,0.001160573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000840559,"threshold_uncertainty_score":0.002385795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003345708423224,"score_gpt":0.2548664682246158,"score_spread":0.2448330111403835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}