{"id":"W3141087639","doi":"10.1093/g3journal/jkaa067","title":"Genetic manipulation of insulin/insulin-like growth factor signaling pathway activity has sex-biased effects on <i>Drosophila</i> body size","year":2021,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Biology; Drosophila (subgenus); Insulin; Insulin receptor; Insulin-like growth factor; Signal transduction; Growth factor; Drosophila melanogaster; Genetics; Cell biology; Endocrinology; Gene; Insulin resistance; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001773491,0.0004751614,0.0006220092,0.0001610505,0.0004298,0.00006782174,0.0005777794,0.0003522463,0.00009256887],"category_scores_gemma":[0.0002272482,0.0004744593,0.0002391401,0.0006178236,0.0003916238,0.00008332169,0.0003314064,0.0005024235,0.00009064554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006756667,"about_ca_system_score_gemma":0.0003626188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000822986,"about_ca_topic_score_gemma":0.000004637009,"domain_scores_codex":[0.9958101,0.001230375,0.0005345449,0.00118035,0.0004781868,0.0007664629],"domain_scores_gemma":[0.9964327,0.001963935,0.0002999037,0.0008725403,0.0002176116,0.000213358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002030085,0.0003345019,0.003765721,0.0001787688,0.0000374524,0.0001260074,0.000182384,0.001265074,0.9384618,0.00005684947,0.00001665787,0.05537176],"study_design_scores_gemma":[0.001026235,0.0009040598,0.02642174,0.00002278292,0.00002984235,0.00003978718,0.000009212327,0.0006005703,0.9683092,0.001020724,0.001204171,0.0004117043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829912,0.01494391,0.0001550507,0.0001579833,0.0007784083,0.0006059834,0.0001191695,0.00008761367,0.0001607435],"genre_scores_gemma":[0.9861559,0.01173145,0.0003843428,0.001043549,0.0003537663,0.00004603449,0.00002049753,0.00007714343,0.0001873178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05496005,"threshold_uncertainty_score":0.9997707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04669929322789507,"score_gpt":0.2708222093741053,"score_spread":0.2241229161462103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}