{"id":"W3141144532","doi":"10.1158/0008-5472.can-20-2701","title":"Mesothelin-Specific CAR T Cells Target Ovarian Cancer","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; Vetenskapsrådet; Karolinska Institutet; Cancerfonden; Barncancerfonden; Memorial Sloan-Kettering Cancer Center","keywords":"Mesothelin; Ovarian cancer; Cancer research; CD28; Tumor microenvironment; T cell; Cytotoxic T cell; CD8; Immune system; Medicine; Ovarian tumor; Antigen; Cancer; Immunology; Biology; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001486866,0.0002376313,0.0004982931,0.0003653616,0.0002948744,0.0001390586,0.0004039825,0.0002176492,0.1523801],"category_scores_gemma":[0.0001033218,0.0002188323,0.0002045478,0.001659497,0.0003981451,0.00009203733,0.0002870471,0.001595438,0.000746611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00126385,"about_ca_system_score_gemma":0.003061821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001716352,"about_ca_topic_score_gemma":0.0004338188,"domain_scores_codex":[0.9948698,0.0004861046,0.0003487742,0.0008816145,0.0020534,0.001360255],"domain_scores_gemma":[0.9961857,0.0002833379,0.00003795387,0.001166927,0.001679825,0.0006462309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005282409,0.0001468717,0.001652114,0.0001635762,0.0001700306,0.0006994711,0.0005428653,0.0000338037,0.8826852,0.0003591598,0.09320556,0.01981304],"study_design_scores_gemma":[0.00118736,0.00007613437,0.0007641304,0.0001189977,0.000009531316,0.00001865287,0.0002611903,0.0000367727,0.4813019,0.0001594544,0.5159352,0.0001305742],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8471819,0.06074394,0.0001862706,0.02385547,0.001887346,0.002283683,0.0003808659,0.0002190532,0.06326152],"genre_scores_gemma":[0.4381789,0.05432057,0.0014588,0.00145655,0.005779876,0.001503477,0.0001125569,0.0003491544,0.4968401],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4335786,"threshold_uncertainty_score":0.9596422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1157306368628907,"score_gpt":0.4282626992009361,"score_spread":0.3125320623380453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}