{"id":"W3141301508","doi":"10.1111/nan.12715","title":"Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis","year":2021,"lang":"en","type":"article","venue":"Neuropathology and Applied Neurobiology","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Defence Medical Centre","funders":"National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; Brain Tumour Charity; CHILDREN with CANCER UK; Tri-Service General Hospital; National Institute for Health and Care Research; Cancer Research UK; Francis Crick Institute","keywords":"Biology; Cortical dysplasia; Tuberous sclerosis; Cell biology; PI3K/AKT/mTOR pathway; Neuroscience; Signal transduction; Epilepsy; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814736,0.0003063996,0.0002180434,0.001301135,0.0001822128,0.0002234,0.0001818453,0.0002825269,0.0007756992],"category_scores_gemma":[0.0002884658,0.0001035113,0.0002329981,0.0006695591,0.0007470577,0.0001781126,0.0003382478,0.0003732069,0.0001407728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002309348,"about_ca_system_score_gemma":0.0001601833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008861754,"about_ca_topic_score_gemma":0.001090608,"domain_scores_codex":[0.9998292,0.00001913955,0.00001997893,0.00004299497,0.00006019246,0.00002842906],"domain_scores_gemma":[0.9997519,0.00006691876,0.00007996662,0.00001841165,0.00004622855,0.00003663521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004855148,0.00003209107,0.02412863,0.0006243519,0.00007789602,0.001317696,0.0001820215,0.00009076689,0.9619077,0.0001262969,0.000102752,0.01092427],"study_design_scores_gemma":[0.00003057901,0.0006870604,0.7201152,0.0001087795,0.0002326747,0.01863523,0.0009047134,0.0003357088,0.2524507,0.0004807399,0.00599465,0.0000239809],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786938,0.01824683,0.001288383,0.000195475,0.00001159716,0.00001576412,0.0003648879,0.00003135165,0.001151827],"genre_scores_gemma":[0.9893264,0.007956248,0.001484261,0.0001004373,0.00001972819,0.0000299641,0.0006418777,0.000005067632,0.0004360447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301135,"threshold_uncertainty_score":0.002594948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06307611552999338,"score_gpt":0.267362454321197,"score_spread":0.2042863387912037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}