{"id":"W3141529164","doi":"10.3390/molecules26071909","title":"5-Aza-2′-Deoxycytidine and Valproic Acid in Combination with CHIR99021 and A83-01 Induce Pluripotency Genes Expression in Human Adult Somatic Cells","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Instituto Mexicano del Seguro Social; Consejo Nacional de Ciencia y Tecnología","keywords":"Reprogramming; SOX2; Induced pluripotent stem cell; Epigenetics; KLF4; Biology; Somatic cell; Cell biology; Chemistry; Molecular biology; Cancer research; Embryonic stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008034901,0.0002781699,0.0001916525,0.0002074886,0.0000979873,0.0001439326,0.00012569,0.0002165265,0.001034652],"category_scores_gemma":[0.00007288123,0.000132926,0.0001580891,0.0001642425,0.0001028543,0.00006662357,0.0001013969,0.0003575682,0.0003024329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001218981,"about_ca_system_score_gemma":0.0001536774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003369445,"about_ca_topic_score_gemma":0.0007759413,"domain_scores_codex":[0.9998995,0.00001832745,0.0000132572,0.00002176677,0.00003325585,0.00001392988],"domain_scores_gemma":[0.9999554,0.00001164681,0.00001269142,0.000005005009,0.000003609121,0.00001173931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009406502,0.00004540721,0.0001362941,0.00003089515,0.000005777301,0.00004626227,0.000006562943,0.00007727622,0.9964579,0.00002706774,0.00004121363,0.003031205],"study_design_scores_gemma":[0.00004255476,0.0009106753,0.003391868,0.000005124737,0.00001628769,0.0003016752,0.000007115943,0.0004724645,0.9928802,0.00001425308,0.00195396,0.000003712016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919825,0.002686913,0.001293482,0.00006894326,0.00004344384,0.00006904736,0.0003147646,0.00007217933,0.003468681],"genre_scores_gemma":[0.99199,0.001560082,0.003016866,0.00008536071,0.00001416864,0.00009107926,0.0005887892,0.00001258192,0.00264092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034652,"threshold_uncertainty_score":0.003461242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00844636928296734,"score_gpt":0.2410458682443068,"score_spread":0.2325994989613394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}