{"id":"W3141529164","doi":"10.3390/molecules26071909","title":"5-Aza-2′-Deoxycytidine and Valproic Acid in Combination with CHIR99021 and A83-01 Induce Pluripotency Genes Expression in Human Adult Somatic Cells","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Instituto Mexicano del Seguro Social; Consejo Nacional de Ciencia y Tecnología","keywords":"Reprogramming; SOX2; Induced pluripotent stem cell; Epigenetics; KLF4; Biology; Somatic cell; Cell biology; Chemistry; Molecular biology; Cancer research; Embryonic stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486474,0.0001971503,0.0002095582,0.0001334705,0.00007721857,0.00005247569,0.0001186441,0.000154904,0.000009816417],"category_scores_gemma":[0.00005290753,0.0001810383,0.00002467351,0.0001947658,0.0000900398,0.00001324361,0.0002307929,0.0001609971,0.000002214465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002245522,"about_ca_system_score_gemma":0.00006776315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004153339,"about_ca_topic_score_gemma":0.0002997151,"domain_scores_codex":[0.9985235,0.000173623,0.0002492547,0.0005278417,0.0002223694,0.0003034014],"domain_scores_gemma":[0.9994569,0.00001307699,0.00006721172,0.0002843261,0.00008746985,0.00009105017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004391365,0.0001680431,0.006608407,0.0001355752,0.00001100301,0.0001092514,0.0001319672,0.0000376299,0.9914481,0.00002646798,0.00002847263,0.001251177],"study_design_scores_gemma":[0.001757432,0.0002258007,0.02744076,0.0002126022,0.000005909976,0.00003858627,0.0001881568,0.0002895145,0.9693357,0.0001962126,0.00008987915,0.0002194629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953794,0.003567239,0.0002931143,0.0001996324,0.00002659529,0.0002925164,0.000006276253,0.000008504743,0.0002267591],"genre_scores_gemma":[0.9973535,0.001050815,0.001104577,0.00006245443,0.00002372145,0.00004788732,0.0001040322,0.00002848653,0.0002245262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02211241,"threshold_uncertainty_score":0.7382529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00844636928296734,"score_gpt":0.2410458682443068,"score_spread":0.2325994989613394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}