{"id":"W3141537606","doi":"10.1136/gutjnl-2021-324070","title":"Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects","year":2021,"lang":"en","type":"article","venue":"Gut","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Deutsche Forschungsgemeinschaft; National Institute on Aging; National Institutes of Health; Crohn's and Colitis Canada","keywords":"Agonist; Opioid; Colitis; Medicine; Receptor; Pharmacology; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151812,0.0002484998,0.0003434024,0.0001088009,0.00008593147,0.0001606372,0.0001752361,0.0002144135,0.001095259],"category_scores_gemma":[0.0001278104,0.00009926076,0.0001919013,0.00009350912,0.0001859201,0.0001941644,0.000116271,0.0005194527,0.0002206373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001066296,"about_ca_system_score_gemma":0.0001431287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002084969,"about_ca_topic_score_gemma":0.0005413123,"domain_scores_codex":[0.9998899,0.00001491516,0.00001297842,0.0000174233,0.00003241513,0.00003238662],"domain_scores_gemma":[0.9999217,0.00001104074,0.00002774561,0.000009555791,0.000009527691,0.00002035765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003436597,0.00006232419,0.00009134446,0.00005413354,0.000005646393,0.00002896681,0.000006385217,0.0000344055,0.9977576,0.00001969595,0.00002433796,0.001571648],"study_design_scores_gemma":[0.0001311968,0.0046143,0.006633297,0.00002025257,0.00004706076,0.0004087675,0.00004099811,0.0008384837,0.9849523,0.00002696469,0.002279431,0.000006920621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962887,0.001444278,0.001250073,0.00007291332,0.00003039772,0.00002567426,0.0001225698,0.00004229197,0.0007232176],"genre_scores_gemma":[0.9940445,0.001771218,0.002083902,0.00008288128,0.00002743486,0.00005709247,0.0003277887,0.00001221158,0.001592984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001095259,"threshold_uncertainty_score":0.003664017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336277631688275,"score_gpt":0.2339849524772396,"score_spread":0.2206221761603569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}