{"id":"W3141667580","doi":"10.1186/s13063-021-05212-w","title":"Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"W. Garfield Weston Foundation; Alberta Innovates - Health Solutions; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Canada; Alberta Innovates; University of Calgary","keywords":"Medicine; Prebiotic; Osteoarthritis; Gut flora; Internal medicine; Randomized controlled trial; Systemic inflammation; Obesity; Knee pain; Placebo; Physiology; Inflammation; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004763029,0.0002118081,0.001595892,0.00007697521,0.00006188428,0.00003202348,0.0000300465,0.0001244804,0.00002343663],"category_scores_gemma":[0.001118108,0.000142865,0.0001593494,0.00005332494,0.00005902765,0.000004847178,0.00003107606,0.00006705459,5.524877e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000162218,"about_ca_system_score_gemma":0.0001587811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002814103,"about_ca_topic_score_gemma":0.000251325,"domain_scores_codex":[0.9963003,0.002001431,0.001029003,0.0003850923,0.0000985753,0.000185563],"domain_scores_gemma":[0.9986659,0.0004737978,0.0004837062,0.000200772,0.0001228916,0.00005292807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.773424,0.000279686,0.0003125526,0.0004278203,0.0001753138,0.000001790859,0.0001461736,0.000002292651,0.2243948,0.000009039422,0.00008104787,0.0007454877],"study_design_scores_gemma":[0.8800911,0.02620205,0.0007219114,0.0002432746,0.0002016937,0.000005330422,0.00007933229,0.000004612605,0.09213426,0.000008835961,0.0001827378,0.0001248667],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6748343,0.00006296246,0.00003362082,0.00004376318,0.00005236175,0.3249261,0.00002845297,0.000004000418,0.000014463],"genre_scores_gemma":[0.7761683,0.0000102487,0.0001124374,0.00002649955,0.000173866,0.2233215,0.0001053649,0.00001539095,0.00006635692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1322605,"threshold_uncertainty_score":0.5825865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672302846026288,"score_gpt":0.3344574196010172,"score_spread":0.3177343911407543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}