{"id":"W3141667580","doi":"10.1186/s13063-021-05212-w","title":"Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"W. Garfield Weston Foundation; Alberta Innovates - Health Solutions; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Canada; Alberta Innovates; University of Calgary","keywords":"Medicine; Prebiotic; Osteoarthritis; Gut flora; Internal medicine; Randomized controlled trial; Systemic inflammation; Obesity; Knee pain; Placebo; Physiology; Inflammation; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01265003,0.006016891,0.01387506,0.001567777,0.003095372,0.003275832,0.003318499,0.00704202,0.05189941],"category_scores_gemma":[0.01197059,0.002481112,0.005824235,0.002156454,0.003313394,0.003186048,0.001834715,0.005886538,0.007025976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003076526,"about_ca_system_score_gemma":0.01104299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00297162,"about_ca_topic_score_gemma":0.006228746,"domain_scores_codex":[0.9927465,0.003402695,0.000974229,0.0009937414,0.000798247,0.001084586],"domain_scores_gemma":[0.9937065,0.001311069,0.001457407,0.0006386722,0.001505282,0.001381064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9780502,0.008096473,0.0002440378,0.004510685,0.001082366,0.00004723708,0.00006321586,0.0002543332,0.000811476,0.0003313205,0.00167873,0.004829943],"study_design_scores_gemma":[0.9800489,0.01525259,0.0005251822,0.0003732717,0.0005534751,0.00001031637,0.00002573391,0.0002583868,0.0001311798,0.0002871823,0.002512371,0.00002144261],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01304783,0.001400271,0.001275319,0.0004528865,0.0008789772,0.9797367,0.001789553,0.0001377683,0.001280727],"genre_scores_gemma":[0.01210035,0.0006292048,0.002293933,0.000447288,0.0002077374,0.9828792,0.000323485,0.000009590981,0.001109237],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05189941,"threshold_uncertainty_score":0.1736208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672302846026288,"score_gpt":0.3344574196010172,"score_spread":0.3177343911407543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}