{"id":"W3141667735","doi":"10.1016/j.isci.2021.102376","title":"Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Eye Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Manton Center for Orphan Disease Research, Boston Children's Hospital; National Institutes of Health; Vetenskapsrådet; Colorado Department of Natural Resources; Manpei Suzuki Diabetes Foundation; Boston Children's Hospital; Alcon Research Institute; Merck; Alzheimer's Association","keywords":"Retinitis pigmentosa; Retinal; Biology; Retinal degeneration; Retina; Muller glia; Neuroscience; Retinal regeneration; Neuroprotection; Cell biology; Axon; Neuroglia; Photoreceptor cell; Central nervous system; Stem cell; Progenitor cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817315,0.0001060258,0.00006870473,0.00002044533,0.0002304818,0.00007748366,0.0001390898,0.00007484964,0.00009711882],"category_scores_gemma":[0.0001496098,0.0001067768,0.00004570591,0.0001438227,0.00006868702,0.0000169675,0.00009965372,0.00006344922,0.00001143913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001552865,"about_ca_system_score_gemma":0.0001222774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001181099,"about_ca_topic_score_gemma":0.00002461022,"domain_scores_codex":[0.9989164,0.00004716545,0.0001615547,0.0004221713,0.0002296646,0.0002230358],"domain_scores_gemma":[0.9995754,0.000004247425,0.00005790918,0.0001715205,0.0001261196,0.0000648523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009420595,0.00001884932,0.003240401,0.000009185849,0.000003289286,0.000001563836,0.00003370602,0.0001127906,0.9930513,0.00001760653,0.002272188,0.001144924],"study_design_scores_gemma":[0.0002744854,0.00008014226,0.004565431,0.0000144305,0.000005873281,0.00001505525,0.0001064084,0.0006381103,0.9814948,0.00004300139,0.01258924,0.0001729849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894024,0.001111245,0.00710018,0.0001624837,0.0003033141,0.0000675848,0.000005744404,0.00001454888,0.001832477],"genre_scores_gemma":[0.993506,0.0001644573,0.002081246,0.0001056283,0.0001907711,0.00001074717,0.0001250408,0.000009293886,0.00380684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01155646,"threshold_uncertainty_score":0.4354232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008325573623085407,"score_gpt":0.2255627260540198,"score_spread":0.2172371524309344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}