{"id":"W3141667735","doi":"10.1016/j.isci.2021.102376","title":"Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Eye Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Manton Center for Orphan Disease Research, Boston Children's Hospital; National Institutes of Health; Vetenskapsrådet; Colorado Department of Natural Resources; Manpei Suzuki Diabetes Foundation; Boston Children's Hospital; Alcon Research Institute; Merck; Alzheimer's Association","keywords":"Retinitis pigmentosa; Retinal; Biology; Retinal degeneration; Retina; Muller glia; Neuroscience; Retinal regeneration; Neuroprotection; Cell biology; Axon; Neuroglia; Photoreceptor cell; Central nervous system; Stem cell; Progenitor cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328983,0.0002710171,0.0002346163,0.0003044882,0.00024541,0.0003176368,0.0001776128,0.0003270485,0.0008064697],"category_scores_gemma":[0.0001872314,0.0001120862,0.0002251846,0.0001103794,0.0002429387,0.0002053217,0.0001617503,0.0003673778,0.0001926124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002989062,"about_ca_system_score_gemma":0.0001725938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001610056,"about_ca_topic_score_gemma":0.002204327,"domain_scores_codex":[0.9998702,0.00002367841,0.00001288747,0.00001770342,0.00003221244,0.0000433214],"domain_scores_gemma":[0.9998889,0.00001629001,0.00002610956,0.0000182584,0.00001868527,0.00003168016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001207542,0.00001138734,0.0001390915,0.00002169018,0.00000462747,0.0001454753,0.00001654189,0.00002939785,0.9977618,0.00006727387,0.00002813763,0.001653811],"study_design_scores_gemma":[0.00001473639,0.0002314981,0.00837889,0.000008788952,0.00002481066,0.0004965488,0.00006134926,0.0002978235,0.9876001,0.00008807902,0.0027918,0.00000564302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994173,0.002341665,0.001146904,0.00008681425,0.00004079349,0.00001210826,0.0001364262,0.00006732351,0.001995076],"genre_scores_gemma":[0.996425,0.0007026431,0.0005751708,0.00002516921,0.00001016123,0.00001264803,0.0001174102,0.00001506237,0.002116641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001610056,"threshold_uncertainty_score":0.003201365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008325573623085407,"score_gpt":0.2255627260540198,"score_spread":0.2172371524309344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}