{"id":"W3141957935","doi":"10.1158/2159-8290.cd-20-1301","title":"The Future of Clinical Trial Design in Oncology","year":2021,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute","keywords":"Clinical trial; Drug development; Clinical research; Clinical study design; Clinical Oncology; Alternative medicine; Cancer; Action (physics); Cancer treatment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4636074,0.002165729,0.007171672,0.004347048,0.001761033,0.01534458,0.004979646,0.008835492,0.00797128],"category_scores_gemma":[0.6155992,0.001690117,0.002748115,0.004234803,0.02360416,0.01416368,0.007174609,0.01627313,0.001941124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007448655,"about_ca_system_score_gemma":0.02438967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001387878,"about_ca_topic_score_gemma":0.0008374741,"domain_scores_codex":[0.4730218,0.4970984,0.00954589,0.007273833,0.01211459,0.0009454654],"domain_scores_gemma":[0.2184689,0.7314337,0.01392732,0.02009392,0.01230611,0.003770002],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001958591,0.0002419615,0.003503992,0.00683868,0.001931381,0.0002455768,0.001141423,0.01308993,0.0003324895,0.615383,0.02520212,0.3301309],"study_design_scores_gemma":[0.001110176,0.0007467271,0.0005362786,0.00370914,0.000291039,0.0001519944,0.0002443904,0.01808206,0.0002698023,0.915595,0.05915982,0.0001035095],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.002521442,0.12891,0.6960931,0.1419375,0.01351808,0.003811308,0.0004106622,0.0008483853,0.0119495],"genre_scores_gemma":[0.1221877,0.04751799,0.7512878,0.04179878,0.01558866,0.01809735,0.0003916857,0.0004757837,0.002654158],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5363926,"threshold_uncertainty_score":0.6614677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7164940707419735,"score_gpt":0.6567688773125598,"score_spread":0.05972519342941363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}