{"id":"W3141987501","doi":"10.1101/2021.03.27.437349","title":"Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; BC Children's Hospital","keywords":"CTBS; Progenitor cell; Progenitor; Trophoblast; Biology; Cell biology; Stem cell; Cellular differentiation; Syncytiotrophoblast; Immunology; Genetics; Gene; Fetus; Placenta","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003225339,0.0007822652,0.0006421347,0.0001340495,0.0001939348,0.0003488056,0.0005799001,0.0006837487,0.00002366655],"category_scores_gemma":[0.00007218489,0.0009029881,0.0003718171,0.0002058696,0.0001182554,0.00001564665,0.000457582,0.0006705459,0.000014202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000189895,"about_ca_system_score_gemma":0.0007915043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001595915,"about_ca_topic_score_gemma":0.00001751392,"domain_scores_codex":[0.9964194,0.000194239,0.000694113,0.001561756,0.0004088662,0.0007215776],"domain_scores_gemma":[0.9976464,0.00002106663,0.0003213944,0.001166746,0.0005436192,0.0003008022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009023753,0.0004350713,0.0006899177,0.0003319621,0.0002327679,0.00003190068,0.00003152856,0.002184485,0.9953156,0.000003141808,0.0006518721,0.000001504125],"study_design_scores_gemma":[0.0008861416,0.0001399541,0.001176026,0.0001836269,0.0001455867,2.943777e-8,0.00002161944,0.001915453,0.9933054,6.453754e-7,0.001178842,0.001046611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681752,0.007424208,0.02190233,0.00003745903,0.001295923,0.000552813,0.0004728036,0.0001195904,0.00001964366],"genre_scores_gemma":[0.9936716,0.002211161,0.003088305,0.000238256,0.0003421778,0.000180022,0.00001683721,0.0001982077,0.00005345352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02549635,"threshold_uncertainty_score":0.9993421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009880711380737161,"score_gpt":0.1954376674487681,"score_spread":0.1855569560680309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}