{"id":"W3141987501","doi":"10.1101/2021.03.27.437349","title":"Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; BC Children's Hospital","keywords":"CTBS; Progenitor cell; Progenitor; Trophoblast; Biology; Cell biology; Stem cell; Cellular differentiation; Syncytiotrophoblast; Immunology; Genetics; Gene; Fetus; Placenta","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842121,0.0003077668,0.0002912206,0.0003791714,0.000285011,0.0005967862,0.0003648853,0.0003380223,0.001374014],"category_scores_gemma":[0.0004905267,0.0001712001,0.0003528607,0.0004252918,0.0001976603,0.0002303797,0.0002876809,0.0003360432,0.0003815944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006385488,"about_ca_system_score_gemma":0.0006628165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00956813,"about_ca_topic_score_gemma":0.01031883,"domain_scores_codex":[0.9999239,0.000009370057,0.000003386917,0.00002890362,0.00002254862,0.00001190191],"domain_scores_gemma":[0.9998801,0.00004550084,0.00001896403,0.00001886248,0.00002156245,0.0000150269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003848686,0.0000745478,0.03681443,0.0003458937,0.00009070109,0.0003742935,0.0004125142,0.3377669,0.5691661,0.009042131,0.003230892,0.04229675],"study_design_scores_gemma":[0.000008864829,0.00002696006,0.009331327,0.00001648238,0.00001865027,0.00009206804,0.00007788247,0.9078506,0.07657284,0.001996026,0.003993304,0.00001513984],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8217573,0.0005073,0.1672224,0.0001830235,0.00002279103,0.00003881032,0.005008197,0.001992325,0.003267884],"genre_scores_gemma":[0.9134941,0.0004031114,0.07766039,0.00003569619,0.000005349607,0.00009500645,0.006317259,0.0002434841,0.00174566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00956813,"threshold_uncertainty_score":0.01902485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009880711380737161,"score_gpt":0.1954376674487681,"score_spread":0.1855569560680309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}