{"id":"W3142359615","doi":"10.1093/noajnl/vdab024.064","title":"ETMM-08 METABOLIC REGULATION OF THE EPIGENOME DRIVES LETHAL INFANTILE EPENDYMOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Epigenome; PRC2; Epigenetics; Histone H3; Cell biology; EZH2; Cancer research; Genetics; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668875,0.0003533638,0.0003203316,0.0002785667,0.0002169439,0.0003779109,0.0003058439,0.0005834269,0.002946046],"category_scores_gemma":[0.0001970356,0.0001626112,0.000355718,0.0002024992,0.0002400079,0.00010973,0.0004058559,0.0008565142,0.0009119879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004860534,"about_ca_system_score_gemma":0.000309007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008639145,"about_ca_topic_score_gemma":0.001524024,"domain_scores_codex":[0.9997454,0.00003674674,0.00003004231,0.00006227838,0.00007155201,0.00005394769],"domain_scores_gemma":[0.9998035,0.00004153349,0.00005544793,0.00002556619,0.00001280622,0.0000612724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001512509,0.00007510869,0.0007126423,0.000044819,0.000009851712,0.0004874211,0.00001667552,0.0002799009,0.9947279,0.0003282331,0.0002694169,0.002896751],"study_design_scores_gemma":[0.00003867676,0.0004171919,0.01273721,0.00002008839,0.00003424141,0.001905422,0.00006360794,0.004406658,0.9654114,0.0002087654,0.01474101,0.00001572138],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780856,0.00134349,0.01015694,0.0004678452,0.0001705,0.00009752706,0.004487324,0.000774739,0.004416147],"genre_scores_gemma":[0.9864515,0.000469253,0.004188983,0.0001966245,0.00001439747,0.00009733201,0.002214296,0.0001129054,0.006254869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002946046,"threshold_uncertainty_score":0.009855509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007906055998120913,"score_gpt":0.2645812904227797,"score_spread":0.2566752344246588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}