{"id":"W3142534304","doi":"10.1038/s41587-021-00880-0","title":"mRNA vaccines take on immune tolerance","year":2021,"lang":"en","type":"letter","venue":"Nature Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Immune system; Messenger RNA; Immunology; Immune tolerance; Biology; Autoimmune disease; Virology; Antibody; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.00007033474,0.000501256,0.0005027651,0.0002087376,0.00007892628,0.00003410859,0.0009001325,0.01191163,0.0001075377],"category_scores_gemma":[0.0001559225,0.0004609844,0.000300656,0.0002080912,0.0001126732,0.000002144123,0.0002912687,0.004691226,0.0001108076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002946619,"about_ca_system_score_gemma":0.0001157438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001241235,"about_ca_topic_score_gemma":0.00001823728,"domain_scores_codex":[0.9978219,0.00006202919,0.0003271267,0.001070644,0.0001976045,0.0005207071],"domain_scores_gemma":[0.998139,0.00001818011,0.0001989286,0.001444756,0.0001695823,0.00002959558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000398661,0.00002357538,0.00001175441,0.0000337855,0.0001170784,0.0002699952,0.000002092936,0.000002447375,0.2592835,0.0000308969,0.7374201,0.002764896],"study_design_scores_gemma":[0.0001706549,0.0002694124,0.00003495723,0.0000605669,0.00001844402,0.00008180792,0.000004656851,0.00000123809,0.4216309,0.00003829411,0.5774024,0.0002866566],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.07581517,0.03974112,0.0000660268,0.8771334,0.004100862,0.000361403,0.0002273943,0.0001591198,0.002395488],"genre_scores_gemma":[0.1072321,0.005732736,0.0004162389,0.8585147,0.008610629,0.00006969955,0.003909933,0.0001463613,0.01536759],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1623474,"threshold_uncertainty_score":0.9997842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006580574110347378,"score_gpt":0.233097840007421,"score_spread":0.2265172658970736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}