{"id":"W3142534304","doi":"10.1038/s41587-021-00880-0","title":"mRNA vaccines take on immune tolerance","year":2021,"lang":"en","type":"letter","venue":"Nature Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Immune system; Messenger RNA; Immunology; Immune tolerance; Biology; Autoimmune disease; Virology; Antibody; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002639459,0.0007104835,0.0007702149,0.0005071539,0.00257079,0.003354917,0.0009078822,0.02971535,0.005655549],"category_scores_gemma":[0.008179449,0.0004902268,0.0006408936,0.0002622741,0.003345378,0.002484013,0.001164769,0.02069616,0.003824108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003627454,"about_ca_system_score_gemma":0.001665157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002761444,"about_ca_topic_score_gemma":0.005721888,"domain_scores_codex":[0.998013,0.0004173755,0.000102882,0.0001973071,0.0009363664,0.0003330528],"domain_scores_gemma":[0.9973311,0.00182294,0.000133822,0.00009969904,0.0003101243,0.0003022353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001793248,0.0000739043,0.0001970319,0.00008648566,0.00001869638,0.001085933,0.00008099223,0.0001587686,0.002043357,0.03530985,0.9273462,0.03341947],"study_design_scores_gemma":[0.0001715872,0.0001122336,0.0003966903,0.00006715013,0.00001794851,0.0006607219,0.00008541877,0.000632322,0.003013752,0.03540254,0.9594078,0.00003189675],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001344452,0.006851017,0.001413178,0.9143812,0.05376774,0.00003768766,0.00006067443,0.0001209393,0.02202303],"genre_scores_gemma":[0.02049596,0.005544815,0.00124543,0.8490399,0.04570426,0.0001367941,0.00004746168,0.00008567743,0.07769965],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02971535,"threshold_uncertainty_score":0.02631909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006580574110347378,"score_gpt":0.233097840007421,"score_spread":0.2265172658970736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}