{"id":"W3142552548","doi":"10.1016/j.ejps.2021.105823","title":"New insights into cytotoxic mechanisms of bozepinib against glioblastoma","year":2021,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Crohn's and Colitis Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Natural Sciences and Engineering Research Council of Canada; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Purinergic receptor; Viability assay; Apoptosis; PI3K/AKT/mTOR pathway; Glioma; Cancer research; Cell cycle; Temozolomide; Cytotoxic T cell; Cancer cell; Protein kinase B; Biology; Chemistry; Adenosine; Cell biology; Cancer; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002456028,0.0004382615,0.0004392913,0.000494023,0.0001603055,0.0008881836,0.0003401912,0.0002935525,0.002187982],"category_scores_gemma":[0.0001173122,0.0001866738,0.0002833463,0.0002799282,0.0002490097,0.0007217007,0.0002626745,0.000967738,0.0003337675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005152013,"about_ca_system_score_gemma":0.0003972676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003719591,"about_ca_topic_score_gemma":0.00123085,"domain_scores_codex":[0.9999256,0.0000125245,0.000005970101,0.0000084949,0.0000214539,0.00002593445],"domain_scores_gemma":[0.9999729,0.000007011663,0.000007322095,0.000002189497,0.000004871375,0.000005750808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002053993,0.0004333124,0.001915103,0.002218203,0.0002219569,0.001868485,0.0002245597,0.002708561,0.6116391,0.02807726,0.006367006,0.3422725],"study_design_scores_gemma":[0.003037299,0.007008616,0.04004759,0.0009914382,0.001371245,0.0106072,0.0007374372,0.01399218,0.3876934,0.04542471,0.4889091,0.0001798351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5339316,0.4081051,0.009034543,0.01003522,0.0006713416,0.0001861141,0.001010829,0.0002758413,0.03674938],"genre_scores_gemma":[0.8160557,0.1735003,0.002058661,0.001618315,0.0003915065,0.00008073854,0.0005003773,0.0000202826,0.005774189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002187982,"threshold_uncertainty_score":0.00731945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02638296502254336,"score_gpt":0.3089115726283668,"score_spread":0.2825286076058235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}