{"id":"W3142761164","doi":"10.2337/db20-1126","title":"Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium–Glucose Cotransporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice","year":2021,"lang":"en","type":"article","venue":"Diabetes","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada; American Society of Nephrology","keywords":"Internal medicine; Endocrinology; Kidney; Transfection; Renal function; Diabetes mellitus; Glucose transporter; Chromatin immunoprecipitation; Cotransporter; Chemistry; Biology; Medicine; Promoter; Gene expression; Sodium; Insulin; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004034546,0.0006942479,0.0007219108,0.00063612,0.0002812143,0.000413934,0.0002635274,0.0005446608,0.001776882],"category_scores_gemma":[0.0001421582,0.0004402748,0.0009252509,0.000395833,0.0004137279,0.0004403447,0.0003067197,0.001236198,0.0003822817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000261137,"about_ca_system_score_gemma":0.0002450499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006268065,"about_ca_topic_score_gemma":0.0009982607,"domain_scores_codex":[0.9995938,0.00005439383,0.00006694845,0.00009586439,0.00008412823,0.0001048243],"domain_scores_gemma":[0.9997136,0.00001873908,0.00009104057,0.00003331705,0.00002631886,0.0001168868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003806437,0.00007937868,0.0004246088,0.00004992352,0.00001643762,0.00006941931,0.00002427222,0.00002189151,0.998495,0.00003431341,0.0000276943,0.0003764537],"study_design_scores_gemma":[0.0001305605,0.001272263,0.01630163,0.0000147375,0.000107658,0.0007146906,0.0001368946,0.0008655792,0.9784771,0.00008288528,0.001879722,0.00001635027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959869,0.0008767809,0.00195125,0.0001426738,0.00004028835,0.00002841666,0.000405518,0.000111826,0.0004564186],"genre_scores_gemma":[0.9924856,0.001240153,0.002274029,0.000171128,0.00002548354,0.00009298161,0.000978744,0.00004333541,0.002688518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001776882,"threshold_uncertainty_score":0.005944252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00435850328542304,"score_gpt":0.211792422655445,"score_spread":0.207433919370022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}