{"id":"W3142793709","doi":"10.1172/jci.insight.138059","title":"TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; Rogel Cancer Center, University of Michigan; BC Cancer Agency; University of Michigan; National Cancer Institute; National Institutes of Health; American Cancer Society","keywords":"Shelterin; Mutagenesis; Haematopoiesis; Cell biology; Computational biology; Biology; Genetics; Mutation; Stem cell; DNA-binding protein; Transcription factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743959,0.0005423328,0.0002168256,0.0002532763,0.0001656828,0.0002508931,0.000335112,0.0003744591,0.001232451],"category_scores_gemma":[0.0002152647,0.0001752621,0.0002221644,0.0002201193,0.0001785062,0.0001849524,0.0003396033,0.0004259875,0.0004391766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002689022,"about_ca_system_score_gemma":0.0002148279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005056201,"about_ca_topic_score_gemma":0.001051169,"domain_scores_codex":[0.999874,0.00002073122,0.00001392787,0.00002887099,0.00004567778,0.00001674757],"domain_scores_gemma":[0.9998794,0.00004198308,0.00003339123,0.00001108776,0.00001363496,0.00002062305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001070401,0.00003331192,0.0006731577,0.00005897078,0.00001461563,0.0003000684,0.00002638896,0.0006680214,0.9942334,0.0002398042,0.00006851752,0.003576812],"study_design_scores_gemma":[0.00002190341,0.0003319167,0.007444777,0.00002673393,0.0000827721,0.001181669,0.00005933671,0.006235796,0.9803014,0.000230408,0.004070487,0.00001277384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853914,0.0008187646,0.01049466,0.00007314724,0.00001323593,0.00008682333,0.0007418957,0.0002615691,0.002118451],"genre_scores_gemma":[0.9932455,0.0004385406,0.004814103,0.00005253098,0.000002932126,0.00002792577,0.000509864,0.00007189342,0.0008367567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232451,"threshold_uncertainty_score":0.004122913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972356418639794,"score_gpt":0.259162446391363,"score_spread":0.2394388822049651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}