{"id":"W3142881018","doi":"10.1152/ajpcell.00471.2020","title":"Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations","year":2021,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; York University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Mitochondrion; Lactic acidosis; Mitochondrial DNA; Biology; Cell biology; MELAS syndrome; Mitochondrial disease; Mitochondrial myopathy; Mitophagy; mitochondrial fusion; Internal medicine; Endocrinology; Autophagy; Biochemistry; Medicine; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002025315,0.0003135339,0.000348426,0.0002703425,0.0002778786,0.0002603189,0.0001142658,0.0003716863,0.001080609],"category_scores_gemma":[0.0002294426,0.0001080028,0.0003514009,0.0001296693,0.0001613718,0.0001641995,0.0001606225,0.0003481848,0.0002524754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001520516,"about_ca_system_score_gemma":0.0001572906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064356,"about_ca_topic_score_gemma":0.001187993,"domain_scores_codex":[0.9998338,0.0000433571,0.00002869553,0.00003690744,0.00003049541,0.00002660022],"domain_scores_gemma":[0.9998946,0.00003019387,0.00001539355,0.00001168798,0.00001341674,0.0000346787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00295639,0.0002745012,0.004035803,0.0001126881,0.00005946302,0.001941904,0.0001552872,0.0001477611,0.9840703,0.00006007164,0.0002160016,0.00596986],"study_design_scores_gemma":[0.000292788,0.008009018,0.1013764,0.00002672699,0.0001719466,0.01006619,0.0006065454,0.002214814,0.8732118,0.0001163673,0.003879046,0.00002831777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972699,0.001727459,0.0002034166,0.00009081344,0.00004346183,0.00001408758,0.000174961,0.00001763454,0.000458165],"genre_scores_gemma":[0.9984202,0.000584007,0.0003701025,0.00003966338,0.000009209037,0.00001559272,0.0002333938,0.00000361363,0.0003242194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080609,"threshold_uncertainty_score":0.003614962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002389741445504786,"score_gpt":0.2091267097021183,"score_spread":0.2067369682566135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}