{"id":"W3142893490","doi":"10.1021/acsomega.1c00369","title":"Synthesis and Biological Evaluation of Novel Benzhydrylpiperazine-Coupled Nitrobenzenesulfonamide Hybrids","year":2021,"lang":"en","type":"article","venue":"ACS Omega","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"VIT University; Hotchkiss Brain Institute, University of Calgary","keywords":"Cytotoxicity; Hybrid; MTT assay; In vitro; Chemistry; Linker; Piperazine; Mycobacterium tuberculosis; Strain (injury); Biochemistry; Biology; Tuberculosis; Organic chemistry; Medicine; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167563,0.000340554,0.0002020111,0.000134006,0.00009589452,0.0001487149,0.0002369877,0.000313372,0.0008666876],"category_scores_gemma":[0.0001124349,0.000116679,0.0001427944,0.0001368988,0.0001259512,0.0002069907,0.0001564285,0.0002357001,0.0002391126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002602639,"about_ca_system_score_gemma":0.0001133396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004141485,"about_ca_topic_score_gemma":0.0007915398,"domain_scores_codex":[0.9999334,0.00001236149,0.000005013201,0.00001500238,0.00001804366,0.0000162963],"domain_scores_gemma":[0.9999371,0.00001052226,0.00001945227,0.000003990185,0.00001342047,0.00001558008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004533685,0.00001991382,0.00005906181,0.00006832845,0.000007387294,0.00005636889,0.0000208008,0.0002966931,0.9972488,0.0001652255,0.00003612932,0.001975884],"study_design_scores_gemma":[0.00001607062,0.0006212597,0.0009724192,0.000005302794,0.00002196987,0.0001994145,0.00001911866,0.0008184269,0.9937097,0.00003897372,0.003566078,0.00001131939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856163,0.002622056,0.007800707,0.00008041457,0.00002869477,0.00007112836,0.0002513216,0.0001223199,0.003407087],"genre_scores_gemma":[0.9899642,0.001279687,0.005592582,0.00005612999,0.000009635402,0.00006811103,0.0002844677,0.00001428784,0.002730897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008666876,"threshold_uncertainty_score":0.002899349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04237873725536283,"score_gpt":0.2906066835446253,"score_spread":0.2482279462892625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}