{"id":"W3142893490","doi":"10.1021/acsomega.1c00369","title":"Synthesis and Biological Evaluation of Novel Benzhydrylpiperazine-Coupled Nitrobenzenesulfonamide Hybrids","year":2021,"lang":"en","type":"article","venue":"ACS Omega","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"VIT University; Hotchkiss Brain Institute, University of Calgary","keywords":"Cytotoxicity; Hybrid; MTT assay; In vitro; Chemistry; Linker; Piperazine; Mycobacterium tuberculosis; Strain (injury); Biochemistry; Biology; Tuberculosis; Organic chemistry; Medicine; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003683581,0.0001090047,0.0001525984,0.0000253781,0.00004056126,0.00001340021,0.00008003376,0.0001070806,0.00001512276],"category_scores_gemma":[0.0001844971,0.0001003084,0.00005641276,0.00007844531,0.00004233023,0.000002636712,0.00009184347,0.00004182093,0.000001042375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001341543,"about_ca_system_score_gemma":0.0001204761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001624815,"about_ca_topic_score_gemma":0.00002986753,"domain_scores_codex":[0.9991877,0.00004416158,0.0001661563,0.0002837655,0.0001754554,0.0001427506],"domain_scores_gemma":[0.9993516,0.00002553974,0.0000609693,0.0002519869,0.0002634031,0.00004646559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003731701,0.00008092519,0.000304848,0.000008000785,0.00006402343,8.243933e-7,0.00001325904,0.00006621454,0.989956,0.000557834,0.00002505229,0.008885702],"study_design_scores_gemma":[0.0008521228,0.0001056211,0.002349648,0.00001314816,0.00008272327,0.00002333125,0.00005144652,0.001623551,0.99152,0.000467264,0.002771074,0.0001400267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954248,0.002445509,0.001425433,0.0001265684,0.0001038816,0.0001038417,0.00003638697,0.00000590915,0.0003276475],"genre_scores_gemma":[0.9978882,0.000798226,0.0007850044,0.0002326793,0.00009790141,0.00003498268,0.00007376611,0.00001333508,0.00007587784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008745676,"threshold_uncertainty_score":0.4090458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04237873725536283,"score_gpt":0.2906066835446253,"score_spread":0.2482279462892625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}