{"id":"W3142978815","doi":"10.1016/j.neo.2021.02.003","title":"Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin","year":2021,"lang":"en","type":"article","venue":"Neoplasia","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université de Montréal; Hôpital Maisonneuve-Rosemont; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Terry Fox Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Fondation du cancer du sein du Québec; McGill University","keywords":"Canagliflozin; Glutamine; Glucose transporter; Pharmacology; Citric acid cycle; Carbohydrate metabolism; Glucose uptake; Cancer cell; Glycolysis; Chemistry; Metabolism; Mechanism of action; Cancer; Type 2 diabetes; Biochemistry; Biology; Endocrinology; Internal medicine; Diabetes mellitus; Medicine; Amino acid; Insulin; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009352465,0.0001375535,0.0001880209,0.00001141758,0.00008529746,0.00001888343,0.0002005159,0.00008152422,0.0003897794],"category_scores_gemma":[0.00003761488,0.0001065004,0.000110469,0.0001290293,0.00007609414,0.000004267697,0.00006450462,0.00008172348,0.000006490807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001193616,"about_ca_system_score_gemma":0.0002899949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000974292,"about_ca_topic_score_gemma":0.002741794,"domain_scores_codex":[0.9990511,0.00009055008,0.0001923051,0.000270162,0.0001597327,0.0002361709],"domain_scores_gemma":[0.9992467,0.00002007988,0.0000887194,0.0004198303,0.0001553097,0.00006935339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001704813,0.0001266791,0.002597833,0.00006427091,0.0001823408,0.000001763385,0.0005032228,0.00007596106,0.7456401,0.0002616416,0.2082867,0.04224237],"study_design_scores_gemma":[0.0002263385,0.000005827358,0.001540505,0.000004622427,0.00006258052,9.263169e-7,0.0001764061,0.00001318454,0.4996022,0.00002232506,0.4982617,0.00008335889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.574267,0.4228093,0.00001854428,0.0001408637,0.0003466234,0.0000664262,0.0001398147,0.000004405499,0.002207044],"genre_scores_gemma":[0.9185485,0.07388704,0.00009924345,0.001110756,0.0003217284,0.00005800484,0.0001336432,0.00002547264,0.005815607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3489223,"threshold_uncertainty_score":0.4342961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004448969118041327,"score_gpt":0.2256161675442989,"score_spread":0.2211671984262576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}