{"id":"W3142986184","doi":"10.1101/2021.04.06.438619","title":"White Matter Hyperintensities, Grey Matter Atrophy, and Cognitive Decline in Neurodegenerative Diseases","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; National Institute on Aging; Alzheimer Society Research Program; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; GlaxoSmithKline; Novartis Pharmaceuticals Corporation; University of California, San Francisco; Alzheimer Society; U.S. Department of Defense; Eli Lilly and Company; Consortium canadien en neurodégénérescence associée au vieillissement; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Sanofi; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hyperintensity; Dementia; Atrophy; Neuroimaging; White matter; Alzheimer's Disease Neuroimaging Initiative; Fluid-attenuated inversion recovery; Cognitive decline; Psychology; Grey matter; Frontotemporal dementia; Population; Neuroscience; Cardiology; Internal medicine; Pathology; Magnetic resonance imaging; Disease; Medicine; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001691617,0.0004814167,0.0004384144,0.001295394,0.0003959838,0.0007371911,0.000407706,0.0003815888,0.0009879749],"category_scores_gemma":[0.003274705,0.0001950585,0.0004524392,0.001201119,0.0004272578,0.0005368771,0.0006059926,0.0004712103,0.00007313067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003265478,"about_ca_system_score_gemma":0.0004156322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006990725,"about_ca_topic_score_gemma":0.008241385,"domain_scores_codex":[0.9995574,0.000196009,0.00004456212,0.0001043679,0.0000690536,0.00002844063],"domain_scores_gemma":[0.9984803,0.0006010913,0.0005335131,0.00008705062,0.0001269198,0.0001712296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004382136,0.00008470317,0.988634,0.0001067916,0.0004807808,0.0001212988,0.000169249,0.0002231429,0.0003451541,0.00008261826,0.0001912666,0.009122768],"study_design_scores_gemma":[0.000007320558,0.00006021121,0.9991329,0.00001444427,0.00007674978,0.00007685892,0.00005177415,0.0002656511,0.00004891296,0.0001742359,0.00008865241,0.000002221593],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939966,0.004397854,0.0002224293,0.0002000569,0.00001408212,0.00001673001,0.000378204,0.000008165393,0.0007657809],"genre_scores_gemma":[0.9986287,0.0006062192,0.0003047494,0.00003509302,0.00003558405,0.00001724511,0.000210174,0.000001599729,0.0001607363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006990725,"threshold_uncertainty_score":0.0139001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173744389625746,"score_gpt":0.2471770068353244,"score_spread":0.2354395629390669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}