{"id":"W3143072458","doi":"10.1016/j.abb.2021.108841","title":"Leishmania major RUVBL1 has a hexameric conformation in solution and, in the presence of RUVBL2, forms a heterodimer with ATPase activity","year":2021,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Institute of Nutrition, Metabolism and Diabetes; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"ATPase; Leishmania; Virology; Biology; Chemistry; AAA proteins; Toxicology; Genetics; Cell biology; Biochemistry; Enzyme; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000190373,0.0002437577,0.0002901476,0.0002031951,0.0002430938,0.0005328158,0.0003508048,0.0003157023,0.001655069],"category_scores_gemma":[0.0002828718,0.0002323585,0.0001236062,0.0002099111,0.000198921,0.0002727736,0.0002121223,0.0004003858,0.0006323336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003004124,"about_ca_system_score_gemma":0.0001469272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006123856,"about_ca_topic_score_gemma":0.0006424841,"domain_scores_codex":[0.9998195,0.00003897734,0.00001299677,0.00006252628,0.00002847219,0.00003757835],"domain_scores_gemma":[0.9998324,0.00003443892,0.00004129097,0.00001793871,0.00002386595,0.00005007365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000275929,0.00004653781,0.001232756,0.00009817818,0.00003366637,0.00006950168,0.00008141556,0.00007828747,0.9936592,0.0002217744,0.0003776132,0.003825237],"study_design_scores_gemma":[0.0001708824,0.0003638367,0.02836852,0.00004653482,0.0000963031,0.001517056,0.0004092118,0.005085959,0.9440695,0.0006022438,0.01920834,0.00006167996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906989,0.00376058,0.003260225,0.00036434,0.00005129511,0.00001139003,0.0002719122,0.0001492126,0.001432149],"genre_scores_gemma":[0.9951857,0.00053057,0.001157985,0.0001362597,0.00001720893,0.00001194997,0.001011438,0.00001870321,0.001930358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655069,"threshold_uncertainty_score":0.005536795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0175025720323751,"score_gpt":0.2566839311947151,"score_spread":0.23918135916234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}