{"id":"W3143323622","doi":"10.1126/science.abb3099","title":"Imaging cell lineage with a synthetic digital recording system","year":2021,"lang":"en","type":"article","venue":"Science","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institutes of Health; Wellcome Trust; Canadian Aeronautics and Space Institute; Paul G. Allen Family Foundation; Howard Hughes Medical Institute","keywords":"Integrase; Biology; Lineage (genetic); Computational biology; Context (archaeology); Gene; Genetics; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045125,0.00006839092,0.00005368219,0.00002478336,0.00008460719,0.0001091302,0.0001406209,0.00001426643,0.000003030622],"category_scores_gemma":[0.00003720062,0.00005955321,0.00002245385,0.0001963851,0.00009076875,0.000006586724,0.00009512655,0.00003475885,0.000007483553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001303748,"about_ca_system_score_gemma":0.0001120318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000124786,"about_ca_topic_score_gemma":0.000001428994,"domain_scores_codex":[0.9993133,0.000004291641,0.00006993355,0.0002945707,0.0001210889,0.0001968145],"domain_scores_gemma":[0.9995968,0.000004200675,0.0000179183,0.0002427137,0.0000720068,0.00006631728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000002936842,0.000008429844,0.001732901,0.00002440906,0.000001753878,0.00002292967,0.0000243437,0.0004546935,0.9958084,0.00001500825,0.00002256963,0.001881661],"study_design_scores_gemma":[0.0001027809,0.00002699517,0.000317395,0.00003767289,0.000004099656,0.0001458523,0.0002970418,0.001794572,0.993282,0.000001104051,0.003877722,0.0001128277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9213318,0.0007959795,0.06761181,0.00005562981,0.0002142971,0.00005157524,0.000005177807,0.00002638893,0.009907315],"genre_scores_gemma":[0.9977751,0.000008043957,0.001679281,0.00002634967,0.00006428648,0.000002913013,0.000003735143,0.000008289325,0.0004319582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07644332,"threshold_uncertainty_score":0.2428509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00293398612440113,"score_gpt":0.2342304969316419,"score_spread":0.2312965108072408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}