{"id":"W3143471491","doi":"10.1101/2021.03.31.437844","title":"A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Institutes of Health; Universidade Federal do Rio Grande do Sul; National Institute of Environmental Health Sciences; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Royal Society","keywords":"Unfolded protein response; XBP1; DNA damage; DNA glycosylase; DNA repair; Gene knockdown; Chemistry; Mutant; Molecular biology; Biology; Cell biology; Biochemistry; Endoplasmic reticulum; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377564,0.0004020726,0.000267556,0.0001729717,0.0001428275,0.0002697334,0.0001186192,0.000323111,0.001052762],"category_scores_gemma":[0.00008536034,0.0001228099,0.0002920648,0.0001082632,0.0002249901,0.0001915323,0.0002334613,0.0004485398,0.000422951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228576,"about_ca_system_score_gemma":0.0001799382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002891724,"about_ca_topic_score_gemma":0.0003495504,"domain_scores_codex":[0.999886,0.00001491423,0.00001370678,0.00003328075,0.0000271328,0.00002487728],"domain_scores_gemma":[0.9998341,0.00001066941,0.00006290664,0.00002084094,0.0000299265,0.00004159941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005771673,0.000006682624,0.000121178,0.00002467004,0.00000258992,0.00001963161,0.000002972387,0.00001146778,0.9994295,0.00003359598,0.00001205978,0.0002778993],"study_design_scores_gemma":[0.000008498064,0.0001539855,0.00785757,0.00001021689,0.00001344631,0.0002199655,0.00002468672,0.0005411619,0.9889761,0.0000670525,0.002123519,0.000003890129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870448,0.004702982,0.005760334,0.0002409405,0.00009130054,0.00004308601,0.0009015506,0.000174519,0.001040621],"genre_scores_gemma":[0.9939227,0.000870736,0.002211738,0.00007743474,0.00001084658,0.00002095534,0.0008009892,0.00001887831,0.002065609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001052762,"threshold_uncertainty_score":0.00352186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009246838444086684,"score_gpt":0.22713589352428,"score_spread":0.2178890550801933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}