{"id":"W3143744119","doi":"10.1161/circ.142.suppl_3.16427","title":"Abstract 16427: Efficacy and Safety of Inclisiran According to Age: A Pooled Analysis of Phase III Studies (ORION 9, 10 and 11)","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Dyslipidemia; Polypharmacy; Placebo; Internal medicine; Adverse effect; Diabetes mellitus; Clinical endpoint; Clinical trial; Obesity; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01430658,0.001454435,0.005534729,0.001419182,0.0002627361,0.001989918,0.0006205134,0.00102095,0.003474157],"category_scores_gemma":[0.0101366,0.0005320419,0.01251014,0.001833393,0.0005261464,0.001053356,0.0006693747,0.001249736,0.0004294393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004870691,"about_ca_system_score_gemma":0.0009001614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005738972,"about_ca_topic_score_gemma":0.001226392,"domain_scores_codex":[0.9952401,0.002943693,0.000802189,0.0004668249,0.000412617,0.0001346143],"domain_scores_gemma":[0.9925318,0.003368021,0.002882344,0.0005419644,0.0004633642,0.0002124652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.344156,0.000614938,0.02475651,0.04618172,0.4963353,0.0001511035,0.0001304729,0.001589044,0.004504942,0.0002175005,0.003769946,0.0775926],"study_design_scores_gemma":[0.163848,0.02641089,0.1021107,0.00471082,0.6901341,0.0003995635,0.0001200363,0.00111008,0.001675747,0.0007821007,0.008544115,0.0001537441],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3227591,0.6556347,0.004147403,0.001137962,0.0007236794,0.00301974,0.008070945,0.0002981743,0.004208348],"genre_scores_gemma":[0.8965578,0.08839487,0.003440505,0.001867759,0.0008246132,0.001970826,0.005179123,0.0001032407,0.001661351],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01430658,"threshold_uncertainty_score":0.07566136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06869125534784726,"score_gpt":0.3516785679953486,"score_spread":0.2829873126475014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}