{"id":"W3143753348","doi":"10.1111/ajt.16584","title":"Toll-like receptor 3 is an endogenous sensor of cell death and a potential target for induction of long-term cardiac transplant survival","year":2021,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research","keywords":"Necroptosis; Medicine; Programmed cell death; Inflammation; Transplantation; Apoptosis; TLR3; Mitochondrial permeability transition pore; Cancer research; Immunology; Cell biology; Toll-like receptor; Biology; Internal medicine; Immune system; Innate immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002397223,0.0002408006,0.0002213453,0.000131833,0.0001611616,0.0003167333,0.0001790638,0.000210505,0.001527488],"category_scores_gemma":[0.0001307159,0.00005879606,0.000272992,0.00008422238,0.0001625874,0.0002004686,0.0002761271,0.0008323463,0.0002361928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002339038,"about_ca_system_score_gemma":0.0001695017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007836858,"about_ca_topic_score_gemma":0.0001757577,"domain_scores_codex":[0.9998934,0.00002439983,0.000008331502,0.00001257067,0.00001955668,0.00004174166],"domain_scores_gemma":[0.9999022,0.00001218327,0.00003276344,0.000008466726,0.00001317058,0.00003115434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001242933,0.0001829202,0.001731329,0.0001150664,0.00001719259,0.0001777388,0.0000290416,0.0001547059,0.9828568,0.0004910881,0.0002712574,0.01272987],"study_design_scores_gemma":[0.0001694076,0.004275165,0.04089873,0.00004980233,0.0001191101,0.00133192,0.0002487276,0.001738653,0.9426789,0.0007003222,0.007765771,0.00002339247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845276,0.007932386,0.004760178,0.0004784559,0.0002132005,0.00004431726,0.0002176113,0.0001057863,0.001720357],"genre_scores_gemma":[0.996292,0.001223141,0.00109188,0.0001204556,0.00004284107,0.00002258901,0.0001796809,0.000006984001,0.001020427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527488,"threshold_uncertainty_score":0.005109966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536268681641093,"score_gpt":0.2345865188201212,"score_spread":0.2192238320037103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}