{"id":"W3143919588","doi":"10.1101/2021.03.31.437748","title":"Functional, metabolic and transcriptional maturation of stem cell derived beta cells","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biocenter Finland; Helsinki Institute of Life Science, Helsingin Yliopisto; Innovative Medicines Initiative; Vetenskapsrådet; Barndiabetesfonden; European Federation of Pharmaceutical Industries and Associations; Novo Nordisk; Diabetes Wellness Suomi Säätiö; Leona M. and Harry B. Helmsley Charitable Trust; Novo Nordisk Fonden; Academy of Finland; Stiftelsen Familjen Ernfors Fond; University of Alberta; Sigrid Juséliuksen Säätiö","keywords":"Islet; Beta cell; Transcriptome; Biology; Cell biology; Transplantation; Stem cell; Induced pluripotent stem cell; Insulin; Secretion; Exocytosis; Internal medicine; Endocrinology; Gene; Embryonic stem cell; Gene expression; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002851964,0.0002124131,0.0001732102,0.0001769047,0.00008208894,0.000693575,0.0001170696,0.000147114,0.0008263364],"category_scores_gemma":[0.0002532679,0.0001042422,0.0001904509,0.0001636731,0.0001809087,0.0002354611,0.0001812637,0.0004893433,0.0003869621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001393323,"about_ca_system_score_gemma":0.0001757585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001487925,"about_ca_topic_score_gemma":0.000199054,"domain_scores_codex":[0.9998677,0.00001704725,0.00001451771,0.00003755759,0.00004511744,0.00001794282],"domain_scores_gemma":[0.999869,0.00002700468,0.00002452416,0.00001803734,0.00003121698,0.00003019148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004739732,0.000008539148,0.0004681844,0.0000235539,0.00000306097,0.00002345154,0.00002455915,0.0001726197,0.9962959,0.00008696652,0.00004089885,0.002804888],"study_design_scores_gemma":[0.000004691185,0.0001533066,0.007581818,0.00001303272,0.00001585902,0.00009323056,0.00005060507,0.0009212727,0.9860184,0.0001377564,0.005004695,0.000005337673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694284,0.002627171,0.02154422,0.0001000525,0.00005864059,0.00007880418,0.001833954,0.0001993901,0.004129482],"genre_scores_gemma":[0.9789165,0.002012805,0.01228936,0.0001487728,0.00002815506,0.0001063208,0.003147778,0.0001545914,0.003195713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008263364,"threshold_uncertainty_score":0.002764344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01838619604853077,"score_gpt":0.2042952978965108,"score_spread":0.18590910184798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}