{"id":"W3143923801","doi":"10.1101/2021.03.26.437274","title":"Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Virology; Germinal center; Antibody; Adjuvant; Neutralizing antibody; Memory B cell; Potency; Neutralization; Immunity; Coronavirus; Biology; Monoclonal antibody; Immune system; Immunology; Coronavirus disease 2019 (COVID-19); B cell; Medicine; Disease; Infectious disease (medical specialty); Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713668,0.0004013071,0.0002004457,0.0001235872,0.0001957456,0.0003141069,0.0003154781,0.0005539968,0.001599989],"category_scores_gemma":[0.00008162901,0.0001512988,0.0003405613,0.00004006858,0.0001735905,0.0002451899,0.0001660108,0.0003770624,0.0006918493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000407789,"about_ca_system_score_gemma":0.0001990734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004032697,"about_ca_topic_score_gemma":0.0003312325,"domain_scores_codex":[0.9999288,0.000009723371,0.000003180668,0.0000182421,0.00001926702,0.00002070991],"domain_scores_gemma":[0.9999778,0.000002922882,0.000004942538,0.000002051367,0.000005983106,0.00000637714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008550427,0.00004576447,0.0001454076,0.00005048323,0.000007701147,0.0001032015,0.00001349396,0.0004372837,0.996436,0.0007596376,0.0002518028,0.001663692],"study_design_scores_gemma":[0.00004728438,0.0004415073,0.0007156588,0.000006975963,0.00001428609,0.0003785279,0.00001640009,0.006103013,0.9880925,0.0002273879,0.00395174,0.000004840411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616955,0.002545045,0.02303732,0.0008785544,0.0002220418,0.0003453511,0.0004764002,0.0003854645,0.01041427],"genre_scores_gemma":[0.984035,0.0006314183,0.006411385,0.0002526739,0.00001495199,0.0001183312,0.0003457383,0.00002318762,0.008167475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001599989,"threshold_uncertainty_score":0.005352497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04372489502372251,"score_gpt":0.3341552166067398,"score_spread":0.2904303215830173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}