{"id":"W3144086685","doi":"10.1101/2021.03.31.437925","title":"SARS-CoV-2 immune evasion by variant B.1.427/B.1.429","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Fast Grants; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Virology; Antibody; Neutralization; Immune escape; Antigen; Monoclonal antibody; Titer; Neutralizing antibody; Signal peptide; Biology; Immune system; Immunology; Peptide sequence; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546508,0.0002275648,0.0002473147,0.00008242639,0.0001439272,0.0002536359,0.0001425475,0.0003077833,0.0008992952],"category_scores_gemma":[0.0001199619,0.00009919414,0.0002374066,0.00007370336,0.0001432948,0.0001020203,0.0001140427,0.0005568272,0.0004347913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000273717,"about_ca_system_score_gemma":0.0002153418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001855593,"about_ca_topic_score_gemma":0.001222977,"domain_scores_codex":[0.9998648,0.00001910194,0.000009516161,0.0000261931,0.00004345515,0.00003681427],"domain_scores_gemma":[0.9999477,0.000006160341,0.00001273902,0.000006421645,0.00001061296,0.00001635698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001174698,0.00006167383,0.0004517182,0.00001076264,0.000005199312,0.00003104243,0.00001006596,0.00005102223,0.9985917,0.00003428713,0.00005395635,0.0005810942],"study_design_scores_gemma":[0.000111666,0.003709088,0.0408429,0.00001824373,0.00004810578,0.001679969,0.0001001541,0.003686795,0.9455673,0.00009632076,0.004120853,0.00001849697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989972,0.0001462768,0.0001997983,0.00002767894,0.00001170181,0.00001159219,0.0001073396,0.00001342009,0.0004850608],"genre_scores_gemma":[0.997587,0.0001344307,0.0005991174,0.00009752661,0.000006662776,0.00001154808,0.0007056495,0.00000927189,0.0008486995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001855593,"threshold_uncertainty_score":0.003689647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105230959616127,"score_gpt":0.2927208488339115,"score_spread":0.2616685392377502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}